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MedKoo CAT#: 206182

CAS#: 1626387-80-1

Description: AZD3759 is also known as zorifertinib. It is an orally available inhibitor of the epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, AZD3759 binds to and inhibits the activity of EGFR as well as certain mutant forms of EGFR. This prevents EGFR-mediated signaling, and may lead to both induction of cell death and inhibition of tumor growth in EGFR-overexpressing cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.

Price and Availability

Size Price Shipping out time Quantity
25mg USD 90 Same Day
50mg USD 150 Same Day
100mg USD 250 Same Day
200mg USD 450 Same Day
500mg USD 750 Same Day
1g USD 1250 Same Day
2g USD 1950 Same Day
5g USD 2950 Same Day
Inquire bulk and customized quantity

Pricing updated 2020-07-11. Prices are subject to change without notice.

AZD3759, purity > 98%, is in stock. The same day shipping out after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 206182
Name: AZD3759
CAS#: 1626387-80-1
Chemical Formula: C22H23ClFN5O3
Exact Mass: 459.14735
Molecular Weight: 459.91
Elemental Analysis: C, 57.46; H, 5.04; Cl, 7.71; F, 4.13; N, 15.23; O, 10.44

Synonym: AZD3759; AZD-3759; AZD 3759; zorifertinibum; zorifertinib.

IUPAC/Chemical Name: (R)-4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl 2,4-dimethylpiperazine-1-carboxylate


InChi Code: InChI=1S/C22H23ClFN5O3/c1-13-11-28(2)7-8-29(13)22(30)32-19-9-14-17(10-18(19)31-3)25-12-26-21(14)27-16-6-4-5-15(23)20(16)24/h4-6,9-10,12-13H,7-8,11H2,1-3H3,(H,25,26,27)/t13-/m1/s1


Technical Data

white to off-white solid powder

>98% (or refer to the Certificate of Analysis)

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Additional Information



1: Tan CS, Cho BC, Soo RA. Next-generation epidermal growth factor receptor
tyrosine kinase inhibitors in epidermal growth factor receptor -mutant non-small
cell lung cancer. Lung Cancer. 2016 Mar;93:59-68. doi:
10.1016/j.lungcan.2016.01.003. Epub 2016 Jan 8. Review. PubMed PMID: 26898616.

2: Zeng Q, Wang J, Cheng Z, Chen K, Johnström P, Varnäs K, Li DY, Yang ZF, Zhang
X. Discovery and Evaluation of Clinical Candidate AZD3759, a Potent, Oral Active,
Central Nervous System-Penetrant, Epidermal Growth Factor Receptor Tyrosine
Kinase Inhibitor. J Med Chem. 2015 Oct 22;58(20):8200-15. doi:
10.1021/acs.jmedchem.5b01073. Epub 2015 Oct 9. PubMed PMID: 26313252.

  (Last updated: 4/20/2016).