3'-O-Methyladenosine
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MedKoo CAT#: 122528

CAS#: 10300-22-8

Description: 3'-O-Methyladenosine

Chemical Structure

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3'-O-Methyladenosine
CAS# 10300-22-8
Instruction

Theoretical Analysis

MedKoo Cat#: 122528
Name: 3'-O-Methyladenosine
CAS#: 10300-22-8
Chemical Formula: C11H15N5O4
Exact Mass: 281.11
Molecular Weight: 281.270
Elemental Analysis: C, 46.97; H, 5.38; N, 24.90; O, 22.75

Price and Availability

Size Price Availability Quantity
250mg USD 450 2 Weeks
500mg USD 850 2 Weeks
1g USD 1250 2 Weeks
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Synonym: 3'-O-Methyladenosine; 10300-22-8; 3'-o-methyl-d-adenosine; Adenosine, 3'-O-methyl-; 3'-O-methyl-Adenosine

IUPAC/Chemical Name: (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol

InChi Key: RYAFZRROCNNRFK-IOSLPCCCSA-N

InChi Code: InChI=1S/C11H15N5O4/c1-19-8-5(2-17)20-11(7(8)18)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1

SMILES Code: OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C(N=CN=C32)N)O1)O)OC

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 281.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Yano J, Kan LS, Ts'o PO. A simple method of the preparation of
2'-O-methyladenosine. Methylation of adenosine with methyl iodide in anhydrous
alkaline medium. Biochim Biophys Acta. 1980 Apr 17;629(1):178-83. doi:
10.1016/0304-4165(80)90276-7. PMID: 7370305.

2: Hecht SM, Hawrelak SD, Kozarich JW, Schmidt FJ, Bock RM. Chemical
modifications of transfer RNA species. Transfer RNA's terminating in 2'- and
3'-O-methyladenosine. Biochem Biophys Res Commun. 1973 Jun 19;52(4):1341-7. doi:
10.1016/0006-291x(73)90648-7. PMID: 4577827.

3: Chinault AC, Kozarich JW, Hecht SM, Schmidt FJ, Bock RM. Preparation of
Escherichia coli tRNAs terminating of modified nucleosides by the use of
CTP(ATP):tRNA nucleotidyltransferase and polynucleotide phosphorylase.
Biochemistry. 1977 Feb 22;16(4):756-65. doi: 10.1021/bi00623a030. PMID: 319825.

4: Smee DF, Sidwell RW. Anti-cowpox virus activities of certain adenosine
analogs, arabinofuranosyl nucleosides, and 2'-fluoro-arabinofuranosyl
nucleosides. Nucleosides Nucleotides Nucleic Acids. 2004;23(1-2):375-83. doi:
10.1081/ncn-120028334. PMID: 15043161.