2-Iodoadenosine
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 122484

CAS#: 35109-88-7

Description: 2-Iodoadenosine is used in the synthesis of peptides, which are important for biological processes like signal transduction and cell growth.

Chemical Structure

img
2-Iodoadenosine
CAS# 35109-88-7
Instruction

Theoretical Analysis

MedKoo Cat#: 122484
Name: 2-Iodoadenosine
CAS#: 35109-88-7
Chemical Formula: C10H12IN5O4
Exact Mass: 392.99
Molecular Weight: 393.140
Elemental Analysis: C, 30.55; H, 3.08; I, 32.28; N, 17.81; O, 16.28

Price and Availability

Size Price Availability Quantity
250mg USD 250 2 Weeks
1g USD 550 2 Weeks
Bulk inquiry

Synonym: 2-Iodoadenosine; 35109-88-7; 2-Iodo Adenosine; Adenosine, 2-iodo-

IUPAC/Chemical Name: (2R,3R,4S,5R)-2-(6-amino-2-iodo-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

InChi Key: MGEBVSZZNFOIRB-UUOKFMHZSA-N

InChi Code: InChI=1S/C10H12IN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6-,9-/m1/s1

SMILES Code: O[C@H]1[C@H](N2C=NC3=C(N)N=C(I)N=C23)O[C@H](CO)[C@H]1O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 393.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: van Tilburg EW, Gremmen M, von Frijtag Drabbe Künzel J, de Groote M, IJzerman
AP. 2,8-Disubstituted adenosine derivatives as partial agonists for the
adenosine A2A receptor. Bioorg Med Chem. 2003 May 15;11(10):2183-92. doi:
10.1016/s0968-0896(03)00123-8. PMID: 12713828.

2: Matsuda A, Shinozaki M, Miyasaka T, Machida H, Abiru T. Palladium-catalyzed
cross-coupling of 2-iodoadenosine with terminal alkynes: synthesis and
biological activities of 2-alkynyladenosines. Chem Pharm Bull (Tokyo). 1985
Apr;33(4):1766-9. doi: 10.1248/cpb.33.1766. PMID: 3840058.

3: Matsuda A, Shinozaki M, Yamaguchi T, Homma H, Nomoto R, Miyasaka T, Watanabe
Y, Abiru T. Nucleosides and nucleotides. 103. 2-Alkynyladenosines: a novel class
of selective adenosine A2 receptor agonists with potent antihypertensive
effects. J Med Chem. 1992 Jan 24;35(2):241-52. doi: 10.1021/jm00080a007. PMID:
1732541.

4: Persson T, Gronowitz S, Hörnfeldt AB, Johansson NG. Synthesis and antiviral
effects of 2-heteroaryl substituted adenosine and 8-heteroaryl substituted
guanosine derivatives. Bioorg Med Chem. 1995 Oct;3(10):1377-82. doi:
10.1016/0968-0896(95)00127-3. PMID: 8564404.

5: Tomikawa A, Seno M, Sato-Kiyotaki K, Ohtsuki C, Hirai T, Yamaguchi T,
Kawaguchi T, Yoshida S, Saneyoshi M. Synthetic nucleosides and nucleotides. 40.
Selective inhibition of eukaryotic DNA polymerase alpha by 9-(beta-D-
arabinofuranosyl)-2-(p-n-butylanilino) adenine 5'-triphosphate (BuAaraATP) and
its 2'-up azido analog: synthesis and enzymatic evaluations. Nucleosides
Nucleotides. 1998 Jan-Mar;17(1-3):487-501. doi: 10.1080/07328319808005193. PMID:
9708358.