WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 556164
CAS#: 16752-89-9
Description: TGP-377421, also known as TGP-377/421 and Targapre-miR-377/421, is a potent miR-377 and miR-421 inhibitor that binds a functional site in both miRNAs.
MedKoo Cat#: 556164
Name: TGP-377421
CAS#: 16752-89-9
Chemical Formula: C20H16N6
Exact Mass: 340.1436
Molecular Weight: 340.39
Elemental Analysis: C, 70.57; H, 4.74; N, 24.69
Synonym: TGP-377421; TGP 377421; TGP377421; TGP-377/421; TGP 377/421; TGP377/421; Targapre-miR-377/421; Targapre-miR377/421; Targapre-miR 377/421;
IUPAC/Chemical Name: 1H-Benzimidazol-5-amine, 2,2′-(1,3-phenylene)bis-
InChi Key: AQEJANNNADGRSY-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H16N6/c21-13-4-6-15-17(9-13)25-19(23-15)11-2-1-3-12(8-11)20-24-16-7-5-14(22)10-18(16)26-20/h1-10H,21-22H2,(H,23,25)(H,24,26)
SMILES Code: NC1=CC=C2C(N=C(C3=CC=CC(C4=NC5=CC(N)=CC=C5N4)=C3)N2)=C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 340.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Haniff HS, Knerr L, Liu X, Crynen G, Boström J, Abegg D, Adibekian A, Lekah E, Wang KW, Cameron MD, Yildirim I, Lemurell M, Disney MD. Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold-small molecule interactions. Nat Chem. 2020 Oct;12(10):952-961. doi: 10.1038/s41557-020-0514-4. Epub 2020 Aug 24. PMID: 32839603; PMCID: PMC7571259.
