TGP-377421
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 556164

CAS#: 16752-89-9

Description: TGP-377421, also known as TGP-377/421 and Targapre-miR-377/421, is a potent miR-377 and miR-421 inhibitor that binds a functional site in both miRNAs.


Chemical Structure

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TGP-377421
CAS# 16752-89-9

Theoretical Analysis

MedKoo Cat#: 556164
Name: TGP-377421
CAS#: 16752-89-9
Chemical Formula: C20H16N6
Exact Mass: 340.14
Molecular Weight: 340.390
Elemental Analysis: C, 70.57; H, 4.74; N, 24.69

Price and Availability

Size Price Availability Quantity
100mg USD 1650 2 Weeks
200mg USD 2950 2 Weeks
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Synonym: TGP-377421; TGP 377421; TGP377421; TGP-377/421; TGP 377/421; TGP377/421; Targapre-miR-377/421; Targapre-miR377/421; Targapre-miR 377/421;

IUPAC/Chemical Name: 1H-Benzimidazol-5-amine, 2,2′-(1,3-phenylene)bis-

InChi Key: AQEJANNNADGRSY-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H16N6/c21-13-4-6-15-17(9-13)25-19(23-15)11-2-1-3-12(8-11)20-24-16-7-5-14(22)10-18(16)26-20/h1-10H,21-22H2,(H,23,25)(H,24,26)

SMILES Code: NC1=CC=C2C(N=C(C3=CC=CC(C4=NC5=CC(N)=CC=C5N4)=C3)N2)=C1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 340.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Haniff HS, Knerr L, Liu X, Crynen G, Boström J, Abegg D, Adibekian A, Lekah E, Wang KW, Cameron MD, Yildirim I, Lemurell M, Disney MD. Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold-small molecule interactions. Nat Chem. 2020 Oct;12(10):952-961. doi: 10.1038/s41557-020-0514-4. Epub 2020 Aug 24. PMID: 32839603; PMCID: PMC7571259.