WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 122429
CAS#: N/A
Description: ZUH280 is a potent and effective HDAC8 Degrader. SZUH280 effectively induced HDAC8 protein degradation and inhibited cancer cell growth even at low micromolar concentrations. SZUH280 hampers DNA damage repair in cancer cells, promoting cellular radiosensitization. In mice, a single SZUH280 dose induced rapid and prolonged HDAC8 protein degradation in xenograft tumor tissues. Moreover, SZUH280 alone or in combination with irradiation resulted in long-lasting tumor regression in an A549 tumor mouse model.
MedKoo Cat#: 122429
Name: ZUH280
CAS#: N/A
Chemical Formula: C36H34N8O8
Exact Mass: 706.25
Molecular Weight: 706.72
Elemental Analysis: C, 61.18; H, 4.85; N, 15.86; O, 18.11
This product is not in stock, which may be available by custom synthesis.
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Synonym: ZUH280; ZUH 280; ZUH-280
IUPAC/Chemical Name: 1-(4-(2-(2-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)benzyl)-N-hydroxy-1H-indole-6-carboxamide
InChi Key: OCXICBCMNKOWFI-UHFFFAOYSA-N
InChi Code: InChI=1S/C36H34N8O8/c45-31-11-10-29(34(47)38-31)44-35(48)27-2-1-3-28(32(27)36(44)49)37-19-25-21-43(41-39-25)14-15-51-16-17-52-26-8-4-22(5-9-26)20-42-13-12-23-6-7-24(18-30(23)42)33(46)40-50/h1-9,12-13,18,21,29,37,50H,10-11,14-17,19-20H2,(H,40,46)(H,38,45,47)
SMILES Code: O=C1CCC(N2C(C(C=CC=C3NCC4=CN(CCOCCOC5=CC=C(CN6C=CC7=C6C=C(C(NO)=O)C=C7)C=C5)N=N4)=C3C2=O)=O)C(N1)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 706.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
