GDC0134 HCl

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MedKoo CAT#: 122407

CAS#: GDC0134 HCl

Description: GDC-0134 is a dual leucine zipper kinase (DLK) inhibitor with the ability to penetrate the brain. Inhibition of DLK prevents the degeneration of neurons and blocks the activation of JNK, serving as a potential treatment for ALS. GDC-0134 has undergone a phase 1 study for treating patients with amyotrophic lateral sclerosis (ALS).

Chemical Structure

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GDC0134 HCl
CAS# GDC0134 HCl
Instruction

Theoretical Analysis

MedKoo Cat#: 122407
Name: GDC0134 HCl
CAS#: GDC0134 HCl
Chemical Formula: C19H22Cl2F4N6O2
Exact Mass: 440.16
Molecular Weight: 513.319
Elemental Analysis: C, 44.46; H, 4.32; Cl, 13.81; F, 14.80; N, 16.37; O, 6.23

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 1637396-55-4 (isomer)   1637394-01-4 (free base)   GDC0134 HCl    

Synonym: GDC0134 HCl; GDC0134 hydrochloride, GDC-0134; GDC0134; GDC 0134; RG-6000; RG6000; RG 6000;

IUPAC/Chemical Name: 5-(6-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-2-(3,3-difluoropyrrolidin-1-yl)pyrimidin-4-yl)-3-(difluoromethoxy)pyridin-2-amine dihydrochloride

InChi Key: LXENROBZYULMLZ-AQEKLAMFSA-N

InChi Code: InChI=1S/C19H20F4N6O2.2ClH/c20-17(21)31-14-3-10(6-25-16(14)24)13-5-15(29-7-12-4-11(29)8-30-12)27-18(26-13)28-2-1-19(22,23)9-28;;/h3,5-6,11-12,17H,1-2,4,7-9H2,(H2,24,25);2*1H/t11-,12-;;/m0../s1

SMILES Code: NC1=NC=C(C2=NC(N3CC(F)(F)CC3)=NC(N4[C@]5([H])CO[C@](C5)([H])C4)=C2)C=C1OC(F)F.[H]Cl.[H]Cl

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 513.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Katz JS, Rothstein JD, Cudkowicz ME, Genge A, Oskarsson B, Hains AB, Chen C, Galanter J, Burgess BL, Cho W, Kerchner GA, Yeh FL, Ghosh AS, Cheeti S, Brooks L, Honigberg L, Couch JA, Rothenberg ME, Brunstein F, Sharma KR, van den Berg L, Berry JD, Glass JD. A Phase 1 study of GDC-0134, a dual leucine zipper kinase inhibitor, in ALS. Ann Clin Transl Neurol. 2022 Jan;9(1):50-66. doi: 10.1002/acn3.51491. Epub 2022 Jan 10. PMID: 35014217; PMCID: PMC8791798.