XRK3F2 HCl | CAS#2375193-43-2 | Inhibitor | p62-ZZ

XRK3F2 HCl
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 122392

CAS#: 2375193-43-2

Description: XRK3F2 is an inhibitor of p62 (Sequestosome-1)-ZZ/ domain. XRK3F2 Inhibition of p62-ZZ Domain Signaling Rescues Myeloma-Induced GFI1-Driven Epigenetic Repression of the Runx2 Gene in Pre-osteoblasts to Overcome Differentiation Suppression.

Chemical Structure

XRK3F2 HCl

CAS# 2375193-43-2

Instruction

Theoretical Analysis

MedKoo Cat#: 122392
Name: XRK3F2 HCl
CAS#: 2375193-43-2
Chemical Formula: C23H24ClF2NO3
Exact Mass: 435.14
Molecular Weight: 435.900
Elemental Analysis: C, 63.38; H, 5.55; Cl, 8.13; F, 8.72; N, 3.21; O, 11.01

Price and Availability

Size	Price	Availability
5mg	USD 450	2 Weeks
10mg	USD 650	2 Weeks
50mg	USD 1250	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: XRK3F2 HCl; XRK-3F2 HCl; XRK 3F2 HCl

IUPAC/Chemical Name: 2-((3,4-bis((4-fluorobenzyl)oxy)benzyl)amino)ethan-1-ol hydrochloride

InChi Key: OKFZPRHMUQRCLJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H23F2NO3.ClH/c24-20-6-1-17(2-7-20)15-28-22-10-5-19(14-26-11-12-27)13-23(22)29-16-18-3-8-21(25)9-4-18;/h1-10,13,26-27H,11-12,14-16H2;1H

SMILES Code: OCCNCC1=CC(OCC2=CC=C(F)C=C2)=C(OCC3=CC=C(F)C=C3)C=C1.Cl

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 435.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Yang G, Yuan Y, Yuan H, Wang J, Yun H, Geng Y, Zhao M, Li L, Weng Y, Liu Z,
Feng J, Bu Y, Liu L, Wang B, Zhang X. Histone acetyltransferase 1 is a
succinyltransferase for histones and non-histones and promotes tumorigenesis.
EMBO Rep. 2021 Feb 3;22(2):e50967. doi: 10.15252/embr.202050967. Epub 2020 Dec
29. PMID: 33372411; PMCID: PMC7857430.

2: Banks CJ, Rodriguez NW, Gashler KR, Pandya RR, Mortenson JB, Whited MD,
Soderblom EJ, Thompson JW, Moseley MA, Reddi AR, Tessem JS, Torres MP, Bikman
BT, Andersen JL. Acylation of Superoxide Dismutase 1 (SOD1) at K122 Governs
SOD1-Mediated Inhibition of Mitochondrial Respiration. Mol Cell Biol. 2017 Sep
26;37(20):e00354-17. doi: 10.1128/MCB.00354-17. PMID: 28739857; PMCID:
PMC5615182.

3: Nam MH, Smith AJO, Pantcheva MB, Park KU, Brzezinski JA, Galligan JJ, Fritz
K, Wormstone IM, Nagaraj RH. Aspirin inhibits TGFβ2-induced epithelial to
mesenchymal transition of lens epithelial cells: selective acetylation of K56
and K122 in histone H3. Biochem J. 2020 Jan 17;477(1):75-97. doi:
10.1042/BCJ20190540. PMID: 31815277; PMCID: PMC8259308.

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XRK3F2 HCl featured