Thalidomide-Acid
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MedKoo CAT#: 122183

CAS#: 1061605-21-7

Description: Thalidomide-Acid is a linker of Thalidomide which is commonly used as a precursor to PROTAC that hijacks cereblon as the E3 ubiquitin ligase component.


Chemical Structure

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Thalidomide-Acid
CAS# 1061605-21-7

Theoretical Analysis

MedKoo Cat#: 122183
Name: Thalidomide-Acid
CAS#: 1061605-21-7
Chemical Formula: C15H12N2O7
Exact Mass: 332.06
Molecular Weight: 332.268
Elemental Analysis: C, 54.22; H, 3.64; N, 8.43; O, 33.71

Price and Availability

Size Price Availability Quantity
250mg USD 800 2 Weeks
500mg USD 1350 2 Weeks
1g USD 2250 2 Weeks
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Synonym: Thalidomide-Acid

IUPAC/Chemical Name: 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetic acid

InChi Key: ZVWIXIGBWIEDFO-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H12N2O7/c18-10-5-4-8(13(21)16-10)17-14(22)7-2-1-3-9(12(7)15(17)23)24-6-11(19)20/h1-3,8H,4-6H2,(H,19,20)(H,16,18,21)

SMILES Code: O=C1C2=C(C(OCC(O)=O)=CC=C2)C(N1C(CC3)C(NC3=O)=O)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 332.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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