WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 121228

CAS#: Unknown

Description: GCN00628, also known as (S,R,S)-VL285 Phenol-C2-NH2 hydrochloride, is a ProTAC building block. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand with alternative exit vector from the widely used VH032, an alkyl-chain crosslinker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used more quickly to generate ProTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

CAS# Unknown

Theoretical Analysis

MedKoo Cat#: 121228
Name: GCN00628
CAS#: Unknown
Chemical Formula: C31H38ClN5O5S
Exact Mass: 627.2282
Molecular Weight: 628.19
Elemental Analysis: C, 59.27; H, 6.10; Cl, 5.64; N, 11.15; O, 12.73; S, 5.10

Price and Availability

Size Price Availability Quantity
50.0mg USD 710.0 2 Weeks
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Synonym: (S,R,S)-VL285 Phenol-C2-NH2 hydrochloride

IUPAC/Chemical Name: (2S,4R)-N-(2-(2-Aminoethoxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamide hydrochloride


InChi Code: InChI=1S/C31H37N5O5S.ClH/c1-18(2)27(36-15-22-6-4-5-7-24(22)30(36)39)31(40)35-16-23(37)13-25(35)29(38)33-14-21-9-8-20(12-26(21)41-11-10-32)28-19(3)34-17-42-28;/h4-9,12,17-18,23,25,27,37H,10-11,13-16,32H2,1-3H3,(H,33,38);1H/t23-,25+,27+;/m1./s1

SMILES Code: O=C1N([C@H](C(N(C2)[C@H](C(NCC3=CC=C(C=C3OCCN)C(SC=N4)=C4C)=O)C[C@H]2O)=O)C(C)C)CC5=C1C=CC=C5.Cl

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 628.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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50.0mg / USD 710.0