Ulonivirine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 121102

CAS#: 1591823-76-5

Description: Ulonivirine is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor in clinical development with potential for once-weekly oral administration for the treatment of HIV-1 infection.

Chemical Structure

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Ulonivirine
CAS# 1591823-76-5
Instruction

Theoretical Analysis

MedKoo Cat#: 121102
Name: Ulonivirine
CAS#: 1591823-76-5
Chemical Formula: C18H8ClF6N5O3
Exact Mass: 491.02
Molecular Weight: 491.730
Elemental Analysis: C, 43.97; H, 1.64; Cl, 7.21; F, 23.18; N, 14.24; O, 9.76

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Ulonivirine; MK-8507; MK8507; MK 8507

IUPAC/Chemical Name: 3-chloro-5-{[6-oxo-1-{[6-oxo-5-(trifluoromethyl)-1,6- dihydropyridazin-3-yl]methyl}-4-(trifluoromethyl)-1,6- dihydropyrimidin-5-yl]oxy}benzonitrile

InChi Key: YSFHLBYWQCLYIY-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H8ClF6N5O3/c19-9-1-8(5-26)2-11(3-9)33-13-14(18(23,24)25)27-7-30(16(13)32)6-10-4-12(17(20,21)22)15(31)29-28-10/h1-4,7H,6H2,(H,29,31)

SMILES Code: O=C1C(C(F)(F)F)=CC(CN(C=NC(C(F)(F)F)=C2OC3=CC(C#N)=CC(Cl)=C3)C2=O)=NN1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 491.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Ankrom W, Jackson Rudd D, Schaeffer A, Panebianco D, Friedman EJ, Tomek C, Stoch SA, Iwamoto M. Pharmacokinetic and Safety Profile of the Novel HIV Nonnucleoside Reverse Transcriptase Inhibitor MK-8507 in Adults without HIV. Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0093521. doi: 10.1128/AAC.00935-21. Epub 2021 Sep 13. PMID: 34516246; PMCID: PMC8597757.