WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 208444
Description: GB1874 inhibitor of the Wnt pathway that targets the β-cat-TCF4 PPI. GB1874 also affected the proliferation and stemness of Wnt-addicted colorectal cancer (CRC) cells in vitro. Encouragingly, GB1874 inhibited the growth of CRC tumor xenografts in vivo, thus demonstrating its potential for further development into therapeutics against Wnt-associated cancer indications.
MedKoo Cat#: 208444
Chemical Formula: C24H27N3O2S
Exact Mass: 421.1824
Molecular Weight: 421.56
Elemental Analysis: C, 68.38; H, 6.46; N, 9.97; O, 7.59; S, 7.61
This product is not in stock, which may be available by custom synthesis.
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Synonym: GB-1874, GB-18-74
IUPAC/Chemical Name: 2-((5-((4-Ethylphenoxy)methyl)-4-(1-phenylethyl)-4H-1,2,4-triazol-3-yl)thio)cyclopentan-1-one
InChi Key: YXVSHQBEMJQNCX-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H27N3O2S/c1-3-18-12-14-20(15-13-18)29-16-23-25-26-24(30-22-11-7-10-21(22)28)27(23)17(2)19-8-5-4-6-9-19/h4-6,8-9,12-15,17,22H,3,7,10-11,16H2,1-2H3
SMILES Code: O=C1C(SC2=NN=C(COC3=CC=C(CC)C=C3)N2C(C4=CC=CC=C4)C)CCC1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 421.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
Low JL, Du W, Gocha T, Oguz G, Zhang X, Chen MW, Masirevic S, Yim DGR, Tan IBH, Ramasamy A, Fan H, DasGupta R. Molecular docking-aided identification of small molecule inhibitors targeting β-catenin-TCF4 interaction. iScience. 2021 May 15;24(6):102544. doi: 10.1016/j.isci.2021.102544. PMID: 34142050; PMCID: PMC8184503.