WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 556135
CAS#: 874755-26-7
Description: WUN55267, also known as GPR40/FFAR1 modulator 1, is an agonist and an allosteric modulator for Gq-coupled free fatty acid receptor 1 (GPR40/FFAR1). This molecule was first reported in Proceedings of the National Academy of Sciences of the United States of America (2019), 116(14), 7123-7128. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
MedKoo Cat#: 556135
Name: WUN55267
CAS#: 874755-26-7
Chemical Formula: C21H19N5O3
Exact Mass: 389.1488
Molecular Weight: 389.415
Elemental Analysis: C, 64.77; H, 4.92; N, 17.98; O, 12.33
Synonym: GPR40/FFAR1 modulator 1; WUN55267; WUN-55267; WUN 55267;
IUPAC/Chemical Name: 7-((4-amino-6-(o-tolylamino)-1,3,5-triazin-2-yl)methoxy)-4-methyl-2H-chromen-2-one
InChi Key: WCRLDDWRDAIHGO-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H19N5O3/c1-12-5-3-4-6-16(12)23-21-25-18(24-20(22)26-21)11-28-14-7-8-15-13(2)9-19(27)29-17(15)10-14/h3-10H,11H2,1-2H3,(H3,22,23,24,25,26)
SMILES Code: CC1=CC=CC=C1NC2=NC(COC3=CC=C(C(C)=CC(O4)=O)C4=C3)=NC(N)=N2
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 389.415 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Lückmann M, Trauelsen M, Bentsen MA, Nissen TAD, Martins J, Fallah Z, Nygaard MM, Papaleo E, Lindorff-Larsen K, Schwartz TW, Frimurer TM. Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7123-7128. doi: 10.1073/pnas.1811066116. Epub 2019 Mar 14. PMID: 30872479; PMCID: PMC6452680.
