WB214

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 121013

CAS#: 2640723-72-2

Description: WB214 is a MDM2 degrader (IC50 = 1.2 nM). WB214 was identified as the most potent anti-proliferative agent in various leukemia cell lines. WB214 not only effectively induced the degradation of MDM2, but also led to the degradation of p53. Further studies revealed that WB214 degraded MDM2 as a molecular glue. Finally, it was found that WB214 could potently degrade GSPT1, which could rationalize the inhibition of cell growth.

Chemical Structure

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WB214
CAS# 2640723-72-2
Instruction

Theoretical Analysis

MedKoo Cat#: 121013
Name: WB214
CAS#: 2640723-72-2
Chemical Formula: C44H43ClF3N5O7
Exact Mass: 845.28
Molecular Weight: 846.300
Elemental Analysis: C, 62.45; H, 5.12; Cl, 4.19; F, 6.73; N, 8.28; O, 13.23

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: WB214; WB-214; WB 214

IUPAC/Chemical Name: ethyl 3-(2-(tert-butylamino)-1-(7-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)-N-(3,4,5-trifluorobenzyl)hept-6-ynamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate

InChi Key: WGGGBWUFPMJXRU-UHFFFAOYSA-N

InChi Code: InChI=1S/C44H43ClF3N5O7/c1-5-60-43(59)38-36(28-16-15-26(45)21-32(28)49-38)39(41(57)51-44(2,3)4)53(22-24-19-30(46)37(48)31(47)20-24)35(55)14-9-7-6-8-11-25-12-10-13-27-29(25)23-52(42(27)58)33-17-18-34(54)50-40(33)56/h10,12-13,15-16,19-21,33,39,49H,5-7,9,14,17-18,22-23H2,1-4H3,(H,51,57)(H,50,54,56)

SMILES Code: FC1=C(F)C(F)=CC(CN(C(CCCCC#CC2=CC=CC3=C2CN(C4CCC(NC4=O)=O)C3=O)=O)C(C5=C(C(OCC)=O)NC6=CC(Cl)=CC=C56)C(NC(C)(C)C)=O)=C1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 846.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Wang B, Liu J, Tandon I, Wu S, Teng P, Liao J, Tang W. Development of MDM2 degraders based on ligands derived from Ugi reactions: Lessons and discoveries. Eur J Med Chem. 2021 Jul 5;219:113425. doi: 10.1016/j.ejmech.2021.113425. Epub 2021 Apr 4. PMID: 33862513; PMCID: PMC8165035.