WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 556129

CAS#: 1693734-80-3 (EZ mixture)

Description: DEL22379, also known as NPX800, is ERK dimerization inhibitor. DEL-22379 has been reported to inhibit ERK dimerization which was unaffected by drug-resistant mechanism reactivating the ERK signaling.

Chemical Structure

CAS# 1693734-80-3 (EZ mixture)

Theoretical Analysis

MedKoo Cat#: 556129
Name: DEL22379
CAS#: 1693734-80-3 (EZ mixture)
Chemical Formula: C26H28N4O3
Exact Mass: 444.2161
Molecular Weight: 444.53
Elemental Analysis: C, 70.25; H, 6.35; N, 12.60; O, 10.80

Price and Availability

Size Price Availability Quantity
50.0mg USD 750.0 2 Weeks
100.0mg USD 1350.0 2 Weeks
200.0mg USD 2350.0 2 Weeks
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Related CAS #: DEL22379 HCl (EZ mixture)   1693734-80-3 (EZ mixture)   786620-82-4 (E-isomer)   710275-80-2 (Z-isomer)   181222-54-8 (Z-isomer HCl)   181222-52-6 (E-isomer HCl)    

Synonym: DEL22379; DEL-22379; DEL 22379; NPX800; NPX 800; NPX-800;

IUPAC/Chemical Name: N-[2,3-Dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2-oxo-1H-indol-5-yl]-1-piperidinepropanamide


InChi Code: InChI=1S/C26H28N4O3/c1-33-19-6-8-23-20(15-19)17(16-27-23)13-22-21-14-18(5-7-24(21)29-26(22)32)28-25(31)9-12-30-10-3-2-4-11-30/h5-8,13-16,27H,2-4,9-12H2,1H3,(H,28,31)(H,29,32)/b22-13+


Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 444.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Yang Y, Zhou Y, Tao L, Yang T, Zhao Y, Luo Y. Structure-activity relationship study of DEL-22379: ERK dimerization inhibitors with increased safety. Mol Divers. 2021 May;25(2):1051-1075. doi: 10.1007/s11030-020-10088-0. Epub 2020 May 6. PMID: 32377992.


50.0mg / USD 750.0