WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 121011
CAS#: 2711006-74-3
Description: ZXH-4-137 is a PROTAC compound.
MedKoo Cat#: 121011
Name: ZXH-4-137
CAS#: 2711006-74-3
Chemical Formula: C48H62N6O9S
Exact Mass: 898.4299
Molecular Weight: 899.11
Elemental Analysis: C, 64.12; H, 6.95; N, 9.35; O, 16.01; S, 3.57
This product is not in stock, which may be available by custom synthesis.
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Synonym: ZXH4-137; ZXH-4-137; ZXH 4-137
IUPAC/Chemical Name: (2S,4R)-1-((2S)-2-(12-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)dodecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
InChi Key: NNAWEJICUWYRRO-PNYALKDFSA-N
InChi Code: InChI=1S/C48H62N6O9S/c1-29(31-19-21-32(22-20-31)41-30(2)49-28-64-41)50-44(59)36-26-33(55)27-53(36)47(62)42(48(3,4)5)51-38(56)18-13-11-9-7-6-8-10-12-14-25-63-37-17-15-16-34-40(37)46(61)54(45(34)60)35-23-24-39(57)52-43(35)58/h15-17,19-22,28-29,33,35-36,42,55H,6-14,18,23-27H2,1-5H3,(H,50,59)(H,51,56)(H,52,57,58)/t29-,33+,35?,36-,42+/m0/s1
SMILES Code: O[C@H]1CN(C([C@H](C(C)(C)C)NC(CCCCCCCCCCCOC2=C(C(N(C3C(NC(CC3)=O)=O)C4=O)=O)C4=CC=C2)=O)=O)[C@H](C(N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)=O)C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 899.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Powell CE, Du G, Bushman JW, He Z, Zhang T, Fischer ES, Gray NS. Selective degradation-inducing probes for studying cereblon (CRBN) biology. RSC Med Chem. 2021 Jul 6;12(8):1381-1390. doi: 10.1039/d0md00382d. PMID: 34458741; PMCID: PMC8372211.
