WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 208360
CAS#: unknown
Description: Y08624 is a new TRIM24/BRPF1 dual inhibitor
MedKoo Cat#: 208360
Name: Y08624
CAS#: unknown
Chemical Formula: C20H22N2O4S
Exact Mass: 386.13
Molecular Weight: 386.47
Elemental Analysis: C, 62.16; H, 5.74; N, 7.25; O, 16.56; S, 8.30
This product is not in stock, which may be available by custom synthesis.
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Synonym: Y-08624, Y0-8624, Y-0862-4
IUPAC/Chemical Name: N-(1-Acetylindolin-5-yl)-5-cyclopropyl-2-methoxybenzenesulfonamide
InChi Key: GUDHFUSYMUTOKE-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H22N2O4S/c1-13(23)22-10-9-16-11-17(6-7-18(16)22)21-27(24,25)20-12-15(14-3-4-14)5-8-19(20)26-2/h5-8,11-12,14,21H,3-4,9-10H2,1-2H3
SMILES Code: O=S(C1=CC(C2CC2)=CC=C1OC)(NC3=CC4=C(N(C(C)=O)CC4)C=C3)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 386.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Xiang Q, Luo G, Zhang C, Hu Q, Wang C, Wu T, Xu H, Hu J, Zhuang X, Zhang M, Wu S, Xu J, Zhang Y, Liu J, Xu Y. Discovery, optimization and evaluation of 1-(indolin-1-yl)ethan-1-ones as novel selective TRIM24/BRPF1 bromodomain inhibitors. Eur J Med Chem. 2022 Jun 5;236:114311. doi: 10.1016/j.ejmech.2022.114311. Epub 2022 Mar 28. PMID: 35385803.
