GD562

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 208303

CAS#: unknown

Description: GD562 is a new cell-potent peptidomimetic inhibitor. GD562 exhibited improved inhibition of the cellular N-terminal methylation levels of both the regulator of chromosome condensation 1 and the oncoprotein SET with an IC50 value of ~50 µM in human colorectal cancer HCT116 cells. Notably, the inhibitory activity of GD562 for the SET protein increased over 6-fold compared with the previously reported cell-potent inhibitor DC541. Furthermore, GD562 also exhibited over 100-fold selectivity for NTMT1 against several other methyltransferases. Thus, this study provides a valuable probe to investigate the biological functions of NTMT1.


Chemical Structure

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GD562
CAS# unknown

Theoretical Analysis

MedKoo Cat#: 208303
Name: GD562
CAS#: unknown
Chemical Formula: C31H38N4O3
Exact Mass: 514.2944
Molecular Weight: 514.67
Elemental Analysis: C, 72.35; H, 7.44; N, 10.89; O, 9.33

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: gd562, GD-562, gd-562

IUPAC/Chemical Name: (S)-N-((S)-6-Amino-1-oxo-1-(phenethylamino)hexan-2-yl)-1-(2-(naphthalen-1-yl)acetyl)pyrrolidine-2-carboxamide

InChi Key: WJBBVNPWCMAHSH-NSOVKSMOSA-N

InChi Code: InChI=1S/C31H38N4O3/c32-19-7-6-16-27(30(37)33-20-18-23-10-2-1-3-11-23)34-31(38)28-17-9-21-35(28)29(36)22-25-14-8-13-24-12-4-5-15-26(24)25/h1-5,8,10-15,27-28H,6-7,9,16-22,32H2,(H,33,37)(H,34,38)/t27-,28-/m0/s1

SMILES Code: O=C([C@H]1N(C(CC2=C3C=CC=CC3=CC=C2)=O)CCC1)N[C@@H](CCCCN)C(NCCC4=CC=CC=C4)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 514.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Dong G, Iyamu ID, Vilseck JZ, Chen D, Huang R. Improved Cell-Potent and Selective Peptidomimetic Inhibitors of Protein N-Terminal Methyltransferase 1. Molecules. 2022 Feb 18;27(4):1381. doi: 10.3390/molecules27041381. PMID: 35209173; PMCID: PMC8874984.