Chromeceptin
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MedKoo CAT#: 556121

CAS#: 331859-86-0

Description: Chromeceptin is an IGF2 inhibitor. Chromeceptin inhibits Insulin-like growth factor 2 (IGF2) signaling by a process that begins with chromeceptin binding to multifunctional protein 2 (MFP-2). This interaction stimulates the expression of IGF binding protein 1 (IGFBP-1) and suppressor of cytokine signaling-3 (SOCS-3), both of which activate signal transducers and activators of transcription 6 (STAT6) to attenuate IGF signals.

Chemical Structure

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Chromeceptin
CAS# 331859-86-0
Instruction

Theoretical Analysis

MedKoo Cat#: 556121
Name: Chromeceptin
CAS#: 331859-86-0
Chemical Formula: C19H16F3N3O
Exact Mass: 359.12
Molecular Weight: 359.352
Elemental Analysis: C, 63.51; H, 4.49; F, 15.86; N, 11.69; O, 4.45

Price and Availability

Size Price Availability Quantity
25mg USD 450 2 Weeks
50mg USD 750 2 Weeks
100mg USD 1250 2 Weeks
200mg USD 2050 2 Weeks
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Synonym: Chromeceptin; 94G6;

IUPAC/Chemical Name: 2-Amino-3-cyano-7-dimethylamino-4-(3-trifluoromethylphenyl)-4H-chromene

InChi Key: GVINXTXGDDSXFQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H16F3N3O/c1-25(2)13-6-7-14-16(9-13)26-18(24)15(10-23)17(14)11-4-3-5-12(8-11)19(20,21)22/h3-9,17H,24H2,1-2H3

SMILES Code: FC(C1=CC(C2C(C#N)=C(N)OC3=C2C=CC(N(C)C)=C3)=CC=C1)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 359.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zhao Y, Xiong Z, Chen Y, Wang G, Zhao Y. Activation of Insulin-Like Growth Factor-2 Ameliorates Retinal Cell Damage and Exerts Protection in in vitro Model of Diabetic Retinopathy. Neuroimmunomodulation. 2021;28(4):266-275. doi: 10.1159/000515662. Epub 2021 May 5. PMID: 33951651.


2: Seol HS, Akiyama Y, Lee SE, Shimada S, Jang SJ. Loss of miR-100 and miR-125b results in cancer stem cell properties through IGF2 upregulation in hepatocellular carcinoma. Sci Rep. 2020 Dec 8;10(1):21412. doi: 10.1038/s41598-020-77960-9. PMID: 33293585; PMCID: PMC7722933.


3: Park YS, Kim HS, Kim JH, Choi SH, Kim DS, Ryoo ZY, Kim JY, Lee S. NAB2-STAT6 fusion protein mediates cell proliferation and oncogenic progression via EGR-1 regulation. Biochem Biophys Res Commun. 2020 May 28;526(2):287-292. doi: 10.1016/j.bbrc.2020.03.090. Epub 2020 Mar 23. PMID: 32216968.


4: Fanganiello RD, Ishiy FA, Kobayashi GS, Alvizi L, Sunaga DY, Passos-Bueno MR. Increased In Vitro Osteopotential in SHED Associated with Higher IGF2 Expression When Compared with hASCs. Stem Cell Rev Rep. 2015 Aug;11(4):635-44. doi: 10.1007/s12015-015-9592-x. PMID: 25931278.


5: Jung D, Abu-Elheiga L, Ayuzawa R, Gu Z, Shirakawa T, Fujiki Y, Nakatsuji N, Wakil SJ, Uesugi M. Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule. Biochem J. 2012 Dec 15;448(3):409-16. doi: 10.1042/BJ20121158. PMID: 23067267.


6: Uesugi M. [Control and analysis of cells by synthetic small molecules]. Yakugaku Zasshi. 2012;132(5):575-86. Japanese. doi: 10.1248/yakushi.132.575. PMID: 22687693.


7: Ma N, Wang X, Qiao Y, Li F, Hui Y, Zou C, Jin J, Lv G, Peng Y, Wang L, Huang H, Zhou L, Zheng X, Gao X. Coexpression of an intronic microRNA and its host gene reveals a potential role for miR-483-5p as an IGF2 partner. Mol Cell Endocrinol. 2011 Feb 10;333(1):96-101. doi: 10.1016/j.mce.2010.11.027. Epub 2010 Dec 10. PMID: 21146586.


8: Choi Y, Shimogawa H, Murakami K, Ramdas L, Zhang W, Qin J, Uesugi M. Chemical genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2. Chem Biol. 2006 Mar;13(3):241-9. doi: 10.1016/j.chembiol.2005.12.011. PMID: 16638529.