GAS41 inhibitor 19

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 208149

CAS#: unknown

Description: We found that GAS41 is overexpressed in human pancreatic cancer tissues and cell lines, and that its expression increases following the acquisition of GEM resistance. GAS41 binds to H2A.Z.2 and activates Notch and its downstream mediators, thereby regulating stemness and drug resistance. Depletion of GAS41 or H2A.Z.2 was found to down-regulate Notch and to sensitize pancreatic cancer cells to GEM

Chemical Structure

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GAS41 inhibitor 19
CAS# unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 208149
Name: GAS41 inhibitor 19
CAS#: unknown
Chemical Formula: C44H46N8O6S4
Exact Mass: 910.24
Molecular Weight: 911.140
Elemental Analysis: C, 58.00; H, 5.09; N, 12.30; O, 10.54; S, 14.07

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Synonym: GAS41-inhibitor 19, GAS41 inhibitor-19, GAS41-inhibitor-19

IUPAC/Chemical Name: (2S,2'S,4R,4'R)-4,4'-(Butane-1,4-diylbis(oxy))bis(N-(5-(3-(benzo[d]thiazol-2-yl)azetidine-1-carbonyl)thiophen-2-yl)pyrrolidine-2-carboxamide)

InChi Key: NUHGUBQPLSCLGP-CKROWEISSA-N

InChi Code: InChI=1S/C44H46N8O6S4/c53-39(49-37-13-11-35(59-37)43(55)51-21-25(22-51)41-47-29-7-1-3-9-33(29)61-41)31-17-27(19-45-31)57-15-5-6-16-58-28-18-32(46-20-28)40(54)50-38-14-12-36(60-38)44(56)52-23-26(24-52)42-48-30-8-2-4-10-34(30)62-42/h1-4,7-14,25-28,31-32,45-46H,5-6,15-24H2,(H,49,53)(H,50,54)/t27-,28-,31+,32+/m1/s1

SMILES Code: O=C([C@H]1NC[C@H](OCCCCO[C@@H]2C[C@@H](C(NC3=CC=C(C(N4CC(C5=NC6=CC=CC=C6S5)C4)=O)S3)=O)NC2)C1)NC7=CC=C(C(N8CC(C9=NC%10=CC=CC=C%10S9)C8)=O)S7

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 911.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Han, S., Cao, C., Liu, R. et al. GAS41 mediates proliferation and GEM chemoresistance via H2A.Z.2 and Notch1 in pancreatic cancer. Cell Oncol. 45, 429–446 (2022). https://doi.org/10.1007/s13402-022-00675-8