WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 208149
CAS#: unknown
Description: We found that GAS41 is overexpressed in human pancreatic cancer tissues and cell lines, and that its expression increases following the acquisition of GEM resistance. GAS41 binds to H2A.Z.2 and activates Notch and its downstream mediators, thereby regulating stemness and drug resistance. Depletion of GAS41 or H2A.Z.2 was found to down-regulate Notch and to sensitize pancreatic cancer cells to GEM
MedKoo Cat#: 208149
Name: GAS41 inhibitor 19
CAS#: unknown
Chemical Formula: C44H46N8O6S4
Exact Mass: 910.2423
Molecular Weight: 911.14
Elemental Analysis: C, 58.00; H, 5.09; N, 12.30; O, 10.54; S, 14.07
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Synonym: GAS41-inhibitor 19, GAS41 inhibitor-19, GAS41-inhibitor-19
IUPAC/Chemical Name: (2S,2'S,4R,4'R)-4,4'-(Butane-1,4-diylbis(oxy))bis(N-(5-(3-(benzo[d]thiazol-2-yl)azetidine-1-carbonyl)thiophen-2-yl)pyrrolidine-2-carboxamide)
InChi Key: NUHGUBQPLSCLGP-CKROWEISSA-N
InChi Code: InChI=1S/C44H46N8O6S4/c53-39(49-37-13-11-35(59-37)43(55)51-21-25(22-51)41-47-29-7-1-3-9-33(29)61-41)31-17-27(19-45-31)57-15-5-6-16-58-28-18-32(46-20-28)40(54)50-38-14-12-36(60-38)44(56)52-23-26(24-52)42-48-30-8-2-4-10-34(30)62-42/h1-4,7-14,25-28,31-32,45-46H,5-6,15-24H2,(H,49,53)(H,50,54)/t27-,28-,31+,32+/m1/s1
SMILES Code: O=C([C@H]1NC[C@H](OCCCCO[C@@H]2C[C@@H](C(NC3=CC=C(C(N4CC(C5=NC6=CC=CC=C6S5)C4)=O)S3)=O)NC2)C1)NC7=CC=C(C(N8CC(C9=NC%10=CC=CC=C%10S9)C8)=O)S7
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 911.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Han, S., Cao, C., Liu, R. et al. GAS41 mediates proliferation and GEM chemoresistance via H2A.Z.2 and Notch1 in pancreatic cancer. Cell Oncol. 45, 429–446 (2022). https://doi.org/10.1007/s13402-022-00675-8
