WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 556112
CAS#: 59474-01-0 (HCl)
Description: XI-011 (NSC146109), a small-molecule inhibitor of MDMX, showed robust anti-proliferation activity against several cervical cancer cell lines. XI-011 promoted apoptosis of cervical cancer cells via stabilizing p53 and activating its transcription activity. Moreover, XI-011 inhibited the growth of xenograft tumor in HeLa tumor-bearing mice, as well as enhanced the cytotoxic activity of cisplatin both in vitro and in vivo.
MedKoo Cat#: 556112
Name: XI-011 HCl
CAS#: 59474-01-0 (HCl)
Chemical Formula: C17H17ClN2S
Exact Mass:
Molecular Weight: 316.85
Elemental Analysis: C, 64.44; H, 5.41; Cl, 11.19; N, 8.84; S, 10.12
Related CAS #: 740031-90-7 (free base) 59474-01-0 (HCl)
Synonym: XI-011 HCl; XI-011 hydrochloride; XI-011; XI011; XI011; NSC 146109 HCl; NSC146109; NSC146109;
IUPAC/Chemical Name: Carbamimidothioic acid, (10-methyl-9-anthracenyl)methyl ester, monohydrochloride
InChi Key: VIBMUYOXJUCEMA-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H16N2S.ClH/c1-11-12-6-2-4-8-14(12)16(10-20-17(18)19)15-9-5-3-7-13(11)15;/h2-9H,10H2,1H3,(H3,18,19);1H
SMILES Code: NC(SCC1=C2C=CC=CC2=C(C)C3=CC=CC=C13)=N.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 316.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Zhang J, Yu G, Yang Y, Wang Y, Guo M, Yin Q, Yan C, Tian J, Fu F, Wang H. A small-molecule inhibitor of MDMX suppresses cervical cancer cells via the inhibition of E6-E6AP-p53 axis. Pharmacol Res. 2022 Mar;177:106128. doi: 10.1016/j.phrs.2022.106128. Epub 2022 Feb 10. PMID: 35150860.
2: Pellegrino R, Thavamani A, Calvisi DF, Budczies J, Neumann A, Geffers R, Kroemer J, Greule D, Schirmacher P, Nordheim A, Longerich T. Serum Response Factor (SRF) Drives the Transcriptional Upregulation of the MDM4 Oncogene in HCC. Cancers (Basel). 2021 Jan 8;13(2):199. doi: 10.3390/cancers13020199. PMID: 33429878; PMCID: PMC7829828.
3: Miranda PJ, Buckley D, Raghu D, Pang JB, Takano EA, Vijayakumaran R, Teunisse AF, Posner A, Procter T, Herold MJ, Gamell C, Marine JC, Fox SB, Jochemsen A, Haupt S, Haupt Y. MDM4 is a rational target for treating breast cancers with mutant p53. J Pathol. 2017 Apr;241(5):661-670. doi: 10.1002/path.4877. Epub 2017 Mar 1. PMID: 28097652.
4: Roh JL, Park JY, Kim EH. XI-011 enhances cisplatin-induced apoptosis by functional restoration of p53 in head and neck cancer. Apoptosis. 2014 Nov;19(11):1594-602. doi: 10.1007/s10495-014-1026-8. PMID: 25113507.
5: de Lange J, Teunisse AF, Vries MV, Lodder K, Lam S, Luyten GP, Bernal F, Jager MJ, Jochemsen AG. High levels of Hdmx promote cell growth in a subset of uveal melanomas. Am J Cancer Res. 2012;2(5):492-507. Epub 2012 Aug 20. PMID: 22957303; PMCID: PMC3433101.
6: Wang H, Yan C. A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells. Neoplasia. 2011 Jul;13(7):611-9. doi: 10.1593/neo.11438. PMID: 21750655; PMCID: PMC3132847.
