SKF89976A HCl
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MedKoo CAT#: 556097

CAS#: 85375-85-5 (HCl)

Description: SKF89976A is a potent GABA uptake inhibitor, which is selective for GAT-1 (IC50 values are 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). SKF89976A inhibits transport current competitively (Ki = 7 μM) and transmitter-gated current non-competitively (Ki = 0.03 nM). It is able to pass the blood-brain barrier after systemic administration and is active in vivo.


Chemical Structure

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SKF89976A HCl
CAS# 85375-85-5 (HCl)

Theoretical Analysis

MedKoo Cat#: 556097
Name: SKF89976A HCl
CAS#: 85375-85-5 (HCl)
Chemical Formula: C22H26ClNO2
Exact Mass:
Molecular Weight: 371.9
Elemental Analysis: C, 71.05; H, 7.05; Cl, 9.53; N, 3.77; O, 8.60

Price and Availability

Size Price Availability Quantity
25.0mg USD 450.0 2 Weeks
50.0mg USD 750.0 2 Weeks
100.0mg USD 1250.0 2 Weeks
200.0mg USD 1950.0 2 Weeks
500.0mg USD 2950.0 2 Weeks
1.0g USD 4650.0 2 Weeks
2.0g USD 6950.0 2 Weeks
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Related CAS #: 85375-15-1 ( free base)   85375-85-5 (HCl)    

Synonym: SKF89976A HCl; SKF 89976A; SKF-89976A; SKF89976A hydrochloride

IUPAC/Chemical Name: 1-(4,4-diphenylbut-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride

InChi Key: SNGGBKYQZVAQKA-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H25NO2.ClH/c24-22(25)20-13-7-15-23(17-20)16-8-14-21(18-9-3-1-4-10-18)19-11-5-2-6-12-19;/h1-6,9-12,14,20H,7-8,13,15-17H2,(H,24,25);1H

SMILES Code: O=C(C1CN(CC/C=C(C2=CC=CC=C2)/C3=CC=CC=C3)CCC1)O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 371.9 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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