NXPZ-2

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 466290

CAS#: 2254492-08-3

Description: NXPZ-2 is a Keap1−Nrf2 inhibitor. NXPZ-2 directly inhibits the Keap1-Nrf2 protein-protein interaction, in an amyloid beta 1-42 (Aβ1-42) oligomer intracerebroventricularly (i.c.v.) injected mouse model. Behavioral tests showed that NXPZ-2 treatment dose-relatedly ameliorated learning and memory dysfunction in Aβ1-42-treated mice. HE and Nissl staining showed that NXPZ-2 improved brain tissue pathological changes in AD mice by increasing neuron quantity and function. NXPZ-2 could be a promising therapeutic agent against AD, and provided the first set of experimental evidence, in a mouse model, to support Keap1-Nrf2 interaction as a validated target for the Nrf2 reactivation in AD.


Chemical Structure

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NXPZ-2
CAS# 2254492-08-3

Theoretical Analysis

MedKoo Cat#: 466290
Name: NXPZ-2
CAS#: 2254492-08-3
Chemical Formula: C27H27N5O7S2
Exact Mass: 597.14
Molecular Weight: 597.661
Elemental Analysis: C, 54.26; H, 4.55; N, 11.72; O, 18.74; S, 10.73

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: NXPZ-2; NXPZ2; NXPZ 2;

IUPAC/Chemical Name: 2-((N-(4-((4-amino-N-(2-amino-2-oxoethyl)phenyl)sulfonamido)naphthalen-1-yl)-4-methoxyphenyl)sulfonamido)acetamide

InChi Key: DFIZGWXPFCOCFG-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H27N5O7S2/c1-39-19-8-12-21(13-9-19)41(37,38)32(17-27(30)34)25-15-14-24(22-4-2-3-5-23(22)25)31(16-26(29)33)40(35,36)20-10-6-18(28)7-11-20/h2-15H,16-17,28H2,1H3,(H2,29,33)(H2,30,34)

SMILES Code: NC(CN(S(C1=CC=C(N)C=C1)(=O)=O)C2=CC=C(N(S(C3=CC=C(OC)C=C3)(=O)=O)CC(N)=O)C4=CC=CC=C42)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 597.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sun Y, Xu L, Zheng D, Wang J, Liu G, Mo Z, Liu C, Zhang W, Yu J, Xing C, He L, Zhuang C. A potent phosphodiester Keap1-Nrf2 protein-protein interaction inhibitor as the efficient treatment of Alzheimer's disease. Redox Biol. 2023 Aug;64:102793. doi: 10.1016/j.redox.2023.102793. Epub 2023 Jun 24. PMID: 37385075; PMCID: PMC10331597.


2: Yan J, Li Y, Ding L, Hou R, Xing C, Jiang C, Miao Z, Zhuang C. Fragment-Based Discovery of Azocyclic Alkyl Naphthalenesulfonamides as Keap1-Nrf2 Inhibitors for Acute Lung Injury Treatment. J Med Chem. 2023 Jun 22;66(12):8267-8280. doi: 10.1021/acs.jmedchem.3c00686. Epub 2023 May 31. PMID: 37257073.


3: Liu G, Hou R, Xu L, Zhang X, Yan J, Xing C, Xu K, Zhuang C. Crystallography- Guided Optimizations of the Keap1-Nrf2 Inhibitors on the Solvent Exposed Region: From Symmetric to Asymmetric Naphthalenesulfonamides. J Med Chem. 2022 Jun 23;65(12):8289-8302. doi: 10.1021/acs.jmedchem.2c00170. Epub 2022 Jun 10. PMID: 35687391.


4: Zhang L, Xu L, Chen H, Zhang W, Xing C, Qu Z, Yu J, Zhuang C. Structure-based molecular hybridization design of Keap1-Nrf2 inhibitors as novel protective agents of acute lung injury. Eur J Med Chem. 2021 Oct 15;222:113599. doi: 10.1016/j.ejmech.2021.113599. Epub 2021 Jun 5. PMID: 34119834.


5: Sun Y, Huang J, Chen Y, Shang H, Zhang W, Yu J, He L, Xing C, Zhuang C. Direct inhibition of Keap1-Nrf2 Protein-Protein interaction as a potential therapeutic strategy for Alzheimer's disease. Bioorg Chem. 2020 Oct;103:104172. doi: 10.1016/j.bioorg.2020.104172. Epub 2020 Aug 27. PMID: 32890991.