WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 208115
CAS#: 2688745-47-1
Description: Y08284 is a CBP Bromodomain inhibitor for the treatment of prostate cancer.
MedKoo Cat#: 208115
Name: Y08284
CAS#: 2688745-47-1
Chemical Formula: C26H25FN4O4
Exact Mass: 476.186
Molecular Weight: 476.51
Elemental Analysis: C, 65.54; H, 5.29; F, 3.99; N, 11.76; O, 13.43
This product is not in stock, which may be available by custom synthesis.
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Synonym: Y08284; Y-08284; Y 08284
IUPAC/Chemical Name: 3-acetyl-N-(3-(1-cyclopropyl-1H-pyrazol-4-yl)-2-fluoro-5-(1-hydroxyethyl)phenyl)-7-methoxyindolizine-1-carboxamide
InChi Key: KKCORLIQMAQULG-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H25FN4O4/c1-14(32)16-8-20(17-12-28-31(13-17)18-4-5-18)25(27)22(9-16)29-26(34)21-11-23(15(2)33)30-7-6-19(35-3)10-24(21)30/h6-14,18,32H,4-5H2,1-3H3,(H,29,34)
SMILES Code: FC1=C(NC(C2=C3N(C=CC(OC)=C3)C(C(C)=O)=C2)=O)C=C(C(O)C)C=C1C(C=N4)=CN4C5CC5
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 476.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Xiang Q, Wang C, Wu T, Zhang C, Hu Q, Luo G, Hu J, Zhuang X, Zou L, Shen H, Wu X, Zhang Y, Kong X, Liu J, Xu Y. Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer. J Med Chem. 2022 Jan 13;65(1):785-810. doi: 10.1021/acs.jmedchem.1c01864. Epub 2021 Dec 28. PMID: 34962793.
