WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 112053
CAS#: 6136-37-4
Description: 1-Methylxanthine is an active metabolite of caffeine and enhances ionizing radiation-induced DNA double-strand break formation in RKO colorectal cancer cells when used at a concentration of 3 mM.
MedKoo Cat#: 112053
Name: 1-Methylxanthine
CAS#: 6136-37-4
Chemical Formula: C6H6N4O2
Exact Mass: 166.0491
Molecular Weight: 166.14
Elemental Analysis: C, 43.38; H, 3.64; N, 33.72; O, 19.26
Synonym: 1-MTX; 1-MX; 1MTX; 1MX; 1 MTX; 1 MX; 1-Methylxanthine; 1Methylxanthine; 1 Methylxanthine
IUPAC/Chemical Name: 1-methyl-3,7-dihydro-1H-purine-2,6-dione
InChi Key: MVOYJPOZRLFTCP-UHFFFAOYSA-N
InChi Code: InChI=1S/C6H6N4O2/c1-10-5(11)3-4(8-2-7-3)9-6(10)12/h2H,1H3,(H,7,8)(H,9,12)
SMILES Code: O=C1NC2=C(NC=N2)C(N1C)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 166.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Youn H, Hee Kook Y, Oh ET, Jeong SY, Kim C, Kyung Choi E, Uk Lim B, Park HJ. 1-Methylxanthine enhances the radiosensitivity of tumor cells. Int J Radiat Biol. 2009 Feb;85(2):167-74. doi: 10.1080/09553000902741190. PMID: 19280470.
