WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 208091
Description: ZE132 is a novel potent PD-1/PD-L1 interaction inhibitor that promotes cytotoxic T-cell tumour infiltration.
MedKoo Cat#: 208091
Chemical Formula: C37H41ClN4O7S
Exact Mass: 720.2384
Molecular Weight: 721.266
Elemental Analysis: C, 61.61; H, 5.73; Cl, 4.91; N, 7.77; O, 15.53; S, 4.44
Synonym: ZE132; ZE 132; ZE-132; Z E132; Z-E132
IUPAC/Chemical Name: 2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)(3-(dimethylamino)propyl)amino)ethane-1-sulfonic acid
InChi Key: QJSJWFVBDAPNAE-UHFFFAOYSA-N
InChi Code: InChI=1S/C37H41ClN4O7S/c1-26-30(6-4-7-32(26)29-8-9-34-37(18-29)47-14-13-46-34)25-49-36-19-35(48-24-28-16-27(20-39)21-40-22-28)31(17-33(36)38)23-42(11-5-10-41(2)3)12-15-50(43,44)45/h4,6-9,16-19,21-22H,5,10-15,23-25H2,1-3H3,(H,43,44,45)
SMILES Code: CN(CCCN(CCS(=O (O)=O)CC1=C(OCC2=CN=CC(C#N)=C2)C=C(OCC3=CC=CC(C4=CC(OCCO5)=C5C=C4)=C3C)C(Cl)=C1)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 721.266 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Liu C, Zhou F, Yan Z, Shen L, Zhang X, He F, Wang H, Lu X, Yu K, Zhao Y, Zhu D. Discovery of a novel, potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with robust in vivo anti-tumour efficacy. Br J Pharmacol. 2021 Jul;178(13):2651-2670. doi: 10.1111/bph.15457. Epub 2021 May 4. PMID: 33768523.