2-Hydroxyadipic Acid | CAS#18294-85-4 | Tumor tissue reducer

2-Hydroxyadipic Acid
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 112014

CAS#: 18294-85-4

Description: 2-Hydroxyadipic acid is a dicarboxylic fatty acid. Levels of 2-hydroxyadipic acid are decreased in tumor tissue from patients with esophageal squamous cell carcinoma. Urinary 2-hydroxyadipic acid levels are increased in patients with 2-ketoadipic aciduria, a disorder characterized by a deficiency in lysine, hydroxylysine, and tryptophan degradation.

Chemical Structure

2-Hydroxyadipic Acid

CAS# 18294-85-4

Instruction

Theoretical Analysis

MedKoo Cat#: 112014
Name: 2-Hydroxyadipic Acid
CAS#: 18294-85-4
Chemical Formula: C6H10O5
Exact Mass: 162.05
Molecular Weight: 162.140
Elemental Analysis: C, 44.45; H, 6.22; O, 49.34

Price and Availability

Size	Price	Availability
5mg	USD 230	2 Weeks
10mg	USD 450	2 Weeks
50mg	USD 780	2 Weeks
100mg	USD 1125	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: α-Hydroxyadipic Acid; 2-Hydroxyadipic Acid; 2Hydroxyadipic Acid; 2 Hydroxyadipic Acid; αHydroxyadipic Acid; α Hydroxyadipic Acid

IUPAC/Chemical Name: 2-hydroxyhexanedioic acid

InChi Key: OTTXIFWBPRRYOG-UHFFFAOYSA-N

InChi Code: InChI=1S/C6H10O5/c7-4(6(10)11)2-1-3-5(8)9/h4,7H,1-3H2,(H,8,9)(H,10,11)

SMILES Code: O=C(O)CCCC(O)C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMF	2.0	12.33
	DMSO	1.0	6.17
	Ethanol	2.0	12.33
	PBS (pH: 7.2)	5.0	30.84

Preparing Stock Solutions

The following data is based on the product molecular weight 162.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Vy Tran A, Park SK, Jin Lee H, Yong Kim T, Kim Y, Suh YW, Lee KY, Jin Kim Y, Baek J. Efficient Production of Adipic Acid by a Two-Step Catalytic Reaction of Biomass-Derived 2,5-Furandicarboxylic Acid. ChemSusChem. 2022 May 20;15(10):e202200375. doi: 10.1002/cssc.202200375. Epub 2022 Apr 1. PMID: 35293137.

2: Choe U, Sun J, Bailoni E, Chen P, Li Y, Gao B, Wang TTY, Rao J, Yu LL. Chemical Composition of Tomato Seed Flours, and Their Radical Scavenging, Anti- Inflammatory and Gut Microbiota Modulating Properties. Molecules. 2021 Mar 9;26(5):1478. doi: 10.3390/molecules26051478. PMID: 33803186; PMCID: PMC7963151.

3: Calderón C, Santi C, Lämmerhofer M. Chiral separation of disease biomarkers with 2-hydroxycarboxylic acid structure. J Sep Sci. 2018 Mar;41(6):1224-1231. doi: 10.1002/jssc.201701243. Epub 2017 Dec 27. PMID: 29205897.

4: Dang L. A biocatalyst inspired by cancer. Nat Chem Biol. 2012 Nov;8(11):874-5. doi: 10.1038/nchembio.1090. PMID: 23076064.

5: Reitman ZJ, Choi BD, Spasojevic I, Bigner DD, Sampson JH, Yan H. Enzyme redesign guided by cancer-derived IDH1 mutations. Nat Chem Biol. 2012 Nov;8(11):887-9. doi: 10.1038/nchembio.1065. Epub 2012 Sep 23. PMID: 23001033; PMCID: PMC3487689.

6: Parthasarathy A, Pierik AJ, Kahnt J, Zelder O, Buckel W. Substrate specificity of 2-hydroxyglutaryl-CoA dehydratase from Clostridium symbiosum: toward a bio-based production of adipic acid. Biochemistry. 2011 May 3;50(17):3540-50. doi: 10.1021/bi1020056. Epub 2011 Apr 5. Erratum in: Biochemistry. 2011 May 24;50(20):4392. PMID: 21434666.

7: Lin HM, Barnett MP, Roy NC, Joyce NI, Zhu S, Armstrong K, Helsby NA, Ferguson LR, Rowan DD. Metabolomic analysis identifies inflammatory and noninflammatory metabolic effects of genetic modification in a mouse model of Crohn's disease. J Proteome Res. 2010 Apr 5;9(4):1965-75. doi: 10.1021/pr901130s. PMID: 20141220.

8: Jakobs C, de Grauw AJ. A fatal case of 2-keto-, 2-hydroxy- and 2-aminoadipic aciduria: relation of organic aciduria to phenotype? J Inherit Metab Dis. 1992;15(2):279-80. doi: 10.1007/BF01799643. PMID: 1527995.

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