WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 112014
Description: 2-Hydroxyadipic acid is a dicarboxylic fatty acid. Levels of 2-hydroxyadipic acid are decreased in tumor tissue from patients with esophageal squamous cell carcinoma. Urinary 2-hydroxyadipic acid levels are increased in patients with 2-ketoadipic aciduria, a disorder characterized by a deficiency in lysine, hydroxylysine, and tryptophan degradation.
MedKoo Cat#: 112014
Name: 2-Hydroxyadipic Acid
Chemical Formula: C6H10O5
Exact Mass: 162.0528
Molecular Weight: 162.14
Elemental Analysis: C, 44.45; H, 6.22; O, 49.34
Synonym: α-Hydroxyadipic Acid; 2-Hydroxyadipic Acid; 2Hydroxyadipic Acid; 2 Hydroxyadipic Acid; αHydroxyadipic Acid; α Hydroxyadipic Acid
IUPAC/Chemical Name: 2-hydroxyhexanedioic acid
InChi Key: OTTXIFWBPRRYOG-UHFFFAOYSA-N
InChi Code: InChI=1S/C6H10O5/c7-4(6(10)11)2-1-3-5(8)9/h4,7H,1-3H2,(H,8,9)(H,10,11)
SMILES Code: O=C(O)CCCC(O)C(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|PBS (pH: 7.2)||5.0||30.84|
The following data is based on the product molecular weight 162.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
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4: Dang L. A biocatalyst inspired by cancer. Nat Chem Biol. 2012 Nov;8(11):874-5. doi: 10.1038/nchembio.1090. PMID: 23076064.
5: Reitman ZJ, Choi BD, Spasojevic I, Bigner DD, Sampson JH, Yan H. Enzyme redesign guided by cancer-derived IDH1 mutations. Nat Chem Biol. 2012 Nov;8(11):887-9. doi: 10.1038/nchembio.1065. Epub 2012 Sep 23. PMID: 23001033; PMCID: PMC3487689.
6: Parthasarathy A, Pierik AJ, Kahnt J, Zelder O, Buckel W. Substrate specificity of 2-hydroxyglutaryl-CoA dehydratase from Clostridium symbiosum: toward a bio-based production of adipic acid. Biochemistry. 2011 May 3;50(17):3540-50. doi: 10.1021/bi1020056. Epub 2011 Apr 5. Erratum in: Biochemistry. 2011 May 24;50(20):4392. PMID: 21434666.
7: Lin HM, Barnett MP, Roy NC, Joyce NI, Zhu S, Armstrong K, Helsby NA, Ferguson LR, Rowan DD. Metabolomic analysis identifies inflammatory and noninflammatory metabolic effects of genetic modification in a mouse model of Crohn's disease. J Proteome Res. 2010 Apr 5;9(4):1965-75. doi: 10.1021/pr901130s. PMID: 20141220.
8: Jakobs C, de Grauw AJ. A fatal case of 2-keto-, 2-hydroxy- and 2-aminoadipic aciduria: relation of organic aciduria to phenotype? J Inherit Metab Dis. 1992;15(2):279-80. doi: 10.1007/BF01799643. PMID: 1527995.