WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 208051
CAS#: N/A
Description: HDAC6 degrader 14a is a novel PROTAC HDAC6 degrader which is an anti-cancer therapeutic.
MedKoo Cat#: 208051
Name: HDAC6 degrader 14a
CAS#: N/A
Chemical Formula: C40H38N10O9
Exact Mass: 802.2823
Molecular Weight: 802.81
Elemental Analysis: C, 59.85; H, 4.77; N, 17.45; O, 17.94
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Synonym: HDAC6 degrader 14a; HDAC6-degrader-14a; HDAC6degrader14a; HDAC6degrader 14a; HDAC6degrader-14a; HDAC6 degrader14a; HDAC6-degrader14a
IUPAC/Chemical Name: 4-((((2Z,3E)-1'-((1-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methyl)-2'-oxo-[2,3'-biindolinylidene]-3-ylidene)amino)oxy)-N-hydroxybutanamide
InChi Key: DLBCMVGHLAVPJQ-ZQEKUULESA-N
InChi Code: InChI=1S/C40H38N10O9/c51-31-15-14-30(37(53)43-31)50-38(54)26-9-5-11-28(33(26)40(50)56)41-16-19-58-20-17-48-21-23(44-47-48)22-49-29-12-4-2-8-25(29)34(39(49)55)36-35(24-7-1-3-10-27(24)42-36)46-59-18-6-13-32(52)45-57/h1-5,7-12,21,30,41-42,57H,6,13-20,22H2,(H,45,52)(H,43,51,53)/b36-34-,46-35+
SMILES Code: O=C(CCCO/N=C1/C(NC2=C1C=CC=C2)=C3C(C=CC=C4)=C4N(CC5=CN(CCOCCNC6=CC=CC(C(N7C8C(NC(CC8)=O)=O)=O)=C6C7=O)N=N5)C\3=O)NO
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 802.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Bieliauskas AV, Weerasinghe SV, Negmeldin AT, Pflum MK. Structural Requirements of Histone Deacetylase Inhibitors: SAHA Analogs Modified on the Hydroxamic Acid. Arch Pharm (Weinheim). 2016 May;349(5):373-82. doi: 10.1002/ardp.201500472. Epub 2016 Apr 9. PMID: 27062198; PMCID: PMC6927578.
