JBP923

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 208029

CAS#: N/A

Description: JBP923 is a natural anti-inflammatory agent, showing potential for the treatment of inflammatory bowel disease (IBD).

Chemical Structure

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JBP923
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 208029
Name: JBP923
CAS#: N/A
Chemical Formula: C8H14N2O5
Exact Mass: 218.09
Molecular Weight: 218.209
Elemental Analysis: C, 44.03; H, 6.47; N, 12.84; O, 36.66

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: JBP923; JBP 923; JBP-923

IUPAC/Chemical Name: ((2S,4R)-4-hydroxypyrrolidine-2-carbonyl)-L-serine

InChi Key: UVSBYUFDCGZIMR-SRQIZXRXSA-N

InChi Code: InChI=1S/C8H14N2O5/c11-3-6(8(14)15)10-7(13)5-1-4(12)2-9-5/h4-6,9,11-12H,1-3H2,(H,10,13)(H,14,15)/t4-,5+,6+/m1/s1

SMILES Code: O=C(N[C@H](C(O)=O)CO)[C@H]1NC[C@H](O)C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 218.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Jiang Q, Xu Q, Wang Y, Li P, Zhang Y, Wang Y, Sun J, Zhang T, He Z. Modulation of Naturally Occurring Linear Dipeptide Chirality to Reduce the Affinity for Oligopeptide Transporter 1 and Increase Intestinal Stability for an Enhanced Colon-Targeting Effect in the Treatment of Inflammatory Bowel Disease: An Application of trans-4-l-Hydroxyprolyl-l-serine. J Med Chem. 2022 Mar 24;65(6):4565-4577. doi: 10.1021/acs.jmedchem.1c01276. Epub 2021 Nov 29. PMID: 34842428.
2: Jiang Q, Zhang J, Tong P, Gao Y, Lv Y, Wang C, Luo M, Sun M, Wang J, Feng Y, Cao L, Wang G, Wang Y, Kan Q, Zhang T, Wang Y, Liu K, Sun J, He Z. Bioactivatable Pseudotripeptidization of Cyclic Dipeptides To Increase the Affinity toward Oligopeptide Transporter 1 for Enhanced Oral Absorption: An Application to Cyclo(l-Hyp-l-Ser) (JBP485). J Med Chem. 2019 Sep 12;62(17):7708-7721. doi: 10.1021/acs.jmedchem.9b00358. Epub 2019 Sep 3. PMID: 31393124.
3: Guo X, Meng Q, Liu Q, Wang C, Huo X, Zhang Z, Kaku T, Liu K. Simultaneous determination of three dipeptides (JBP485, Gly-Sar and JBP923) in the cell lysates by liquid chromatography-tandem mass spectrometry: application to identify the function of the PEPT1 transfected cell. Biomed Chromatogr. 2014 Dec;28(12):1839-45. doi: 10.1002/bmc.3228. Epub 2014 Jun 6. PMID: 24903899.
4: Liu Z, Wang C, Liu Q, Meng Q, Cang J, Mei L, Kaku T, Liu K. Uptake, transport and regulation of JBP485 by PEPT1 in vitro and in vivo. Peptides. 2011 Apr;32(4):747-54. doi: 10.1016/j.peptides.2011.01.019. Epub 2011 Jan 22. PMID: 21262302.
5: Cang J, Zhang J, Wang C, Liu Q, Meng Q, Wang D, Sugiyama Y, Tsuji A, Kaku T, Liu K. Pharmacokinetics and mechanism of intestinal absorption of JBP485 in rats. Drug Metab Pharmacokinet. 2010;25(5):500-7. doi: 10.2133/dmpk.dmpk-10-rg-045. Epub 2010 Sep 22. PMID: 20877133.
6: Liu KX, Kato Y, Kaku TI, Santa T, Imai K, Yagi A, Ishizu T, Sugiyama Y. Hydroxyprolylserine derivatives JBP923 and JBP485 exhibit the antihepatitis activities after gastrointestinal absorption in rats. J Pharmacol Exp Ther. 2000 Aug;294(2):510-5. PMID: 10900226.