WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 577952
CAS#: 572-76-9
Description: Nandinine is a derivative of berberine that has been shown to inhibit inflammation and reduce insulin resistance.
MedKoo Cat#: 577952
Name: Nandinine
CAS#: 572-76-9
Chemical Formula: C19H19NO4
Exact Mass: 325.1314
Molecular Weight: 325.36
Elemental Analysis: C, 70.14; H, 5.89; N, 4.31; O, 19.67
This product is not in stock, which may be available by custom synthesis.
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Synonym: Nandinine
IUPAC/Chemical Name: (13aS)-5,8,13,13a-Tetrahydro-10-methoxy-6H-benzo(g)-1,3-benzodioxolo(5,6-a)quinolizin-9-ol
InChi Key: PQECCKIOFCWGRJ-HNNXBMFYSA-N
InChi Code: InChI=1S/C19H19NO4/c1-22-16-3-2-11-6-15-13-8-18-17(23-10-24-18)7-12(13)4-5-20(15)9-14(11)19(16)21/h2-3,7-8,15,21H,4-6,9-10H2,1H3/t15-/m0/s1
SMILES Code: COc1ccc2C[C@@H]3N(CCc4cc5OCOc5cc34)Cc2c1O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 325.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Zhao W, Ge H, Liu K, Chen X, Zhang J, Liu B. Nandinine, a Derivative of Berberine, Inhibits Inflammation and Reduces Insulin Resistance in Adipocytes via Regulation of AMP-Kinase Activity. Planta Med. 2017 Feb;83(3-04):203-209. doi: 10.1055/s-0042-110576. Epub 2016 Jul 27. PMID: 27462872.
