WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 577947
CAS#: 119630-94-3
Description: Naloxone benzoylhydrazone is a kappa 3 opioid agonist.
MedKoo Cat#: 577947
Name: Naloxone benzoylhydrazone
CAS#: 119630-94-3
Chemical Formula: C26H27N3O4
Exact Mass: 445.2002
Molecular Weight: 445.52
Elemental Analysis: C, 70.09; H, 6.11; N, 9.43; O, 14.36
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Synonym: Naloxone benzoylhydrazone; Nalbzoh
IUPAC/Chemical Name: Benzoic acid, ((5alpha)-4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene)hydrazide
InChi Key: AKXCFAYOTIEFOH-XTNAHFASSA-N
InChi Code: InChI=1S/C26H27N3O4/c1-2-13-29-14-12-25-21-17-8-9-19(30)22(21)33-23(25)18(10-11-26(25,32)20(29)15-17)27-28-24(31)16-6-4-3-5-7-16/h2-9,20,23,30,32H,1,10-15H2,(H,28,31)/b27-18+/t20-,23+,25+,26-/m1/s1
SMILES Code: Oc1ccc2C[C@H]3N(CC=C)CC[C@@]45[C@@H](Oc1c24)\C(=N\NC(=O)c6ccccc6)\CC[C@@]35O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 445.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Paul D, Levison JA, Howard DH, Pick CG, Hahn EF, Pasternak GW. Naloxone benzoylhydrazone (NalBzoH) analgesia. J Pharmacol Exp Ther. 1990 Nov;255(2):769-74. PMID: 2173757.
2. Koch JE, Pasternak GW, Arjune D, Bodnar RJ. Naloxone benzoylhydrazone, a kappa 3 opioid agonist, stimulates food intake in rats. Brain Res. 1992 May 29;581(2):311-4. doi: 10.1016/0006-8993(92)90723-m. PMID: 1327401.
3. Olianas MC, Concas D, Onali P. Agonist activity of naloxone benzoylhydrazone at recombinant and native opioid receptors. Br J Pharmacol. 2006 Feb;147(4):360-70. doi: 10.1038/sj.bjp.0706601. PMID: 16402046; PMCID: PMC1616995.
