Naloxone benzoylhydrazone

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 577947

CAS#: 119630-94-3

Description: Naloxone benzoylhydrazone is a kappa 3 opioid agonist.

Chemical Structure

Naloxone benzoylhydrazone
CAS# 119630-94-3

Theoretical Analysis

MedKoo Cat#: 577947
Name: Naloxone benzoylhydrazone
CAS#: 119630-94-3
Chemical Formula: C26H27N3O4
Exact Mass: 445.2002
Molecular Weight: 445.52
Elemental Analysis: C, 70.09; H, 6.11; N, 9.43; O, 14.36

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Naloxone benzoylhydrazone; Nalbzoh

IUPAC/Chemical Name: Benzoic acid, ((5alpha)-4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene)hydrazide


InChi Code: InChI=1S/C26H27N3O4/c1-2-13-29-14-12-25-21-17-8-9-19(30)22(21)33-23(25)18(10-11-26(25,32)20(29)15-17)27-28-24(31)16-6-4-3-5-7-16/h2-9,20,23,30,32H,1,10-15H2,(H,28,31)/b27-18+/t20-,23+,25+,26-/m1/s1

SMILES Code: Oc1ccc2C[C@H]3N(CC=C)CC[C@@]45[C@@H](Oc1c24)\C(=N\NC(=O)c6ccccc6)\CC[C@@]35O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 445.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Paul D, Levison JA, Howard DH, Pick CG, Hahn EF, Pasternak GW. Naloxone benzoylhydrazone (NalBzoH) analgesia. J Pharmacol Exp Ther. 1990 Nov;255(2):769-74. PMID: 2173757.

2. Koch JE, Pasternak GW, Arjune D, Bodnar RJ. Naloxone benzoylhydrazone, a kappa 3 opioid agonist, stimulates food intake in rats. Brain Res. 1992 May 29;581(2):311-4. doi: 10.1016/0006-8993(92)90723-m. PMID: 1327401.

3. Olianas MC, Concas D, Onali P. Agonist activity of naloxone benzoylhydrazone at recombinant and native opioid receptors. Br J Pharmacol. 2006 Feb;147(4):360-70. doi: 10.1038/sj.bjp.0706601. PMID: 16402046; PMCID: PMC1616995.