WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 577918
CAS#: 220379-48-6
Description: N-2733 HCl is a nuclear factor (NF)-kappaB activation inhibitor.
MedKoo Cat#: 577918
Name: N-2733 HCl
CAS#: 220379-48-6
Chemical Formula: C12H13ClN2O2
Exact Mass: 252.0666
Molecular Weight: 252.7
Elemental Analysis: C, 57.04; H, 5.19; Cl, 14.03; N, 11.09; O, 12.66
This product is not in stock, which may be available by custom synthesis.
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Synonym: N 2733 HCl; N2733 HCl; N-2733 HCl; N2733 hydrochloride
IUPAC/Chemical Name: 2-Pyrrolidinone, 1-(1-oxo-3-(3-pyridinyl)-2-propen-1-yl)-, hydrochloride (1:1)
InChi Key: JYPXPKYXTLVVIW-IPZCTEOASA-N
InChi Code: 1S/C12H12N2O2.ClH/c15-11-4-2-8-14(11)12(16)6-5-10-3-1-7-13-9-10;/h1,3,5-7,9H,2,4,8H2;1H/b6-5+;
SMILES Code: Cl.O=C(\C=C\c1cccnc1)N2CCCC2=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 252.7 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Mitaka C, Hirata Y, Narumi Y, Yokoyama K, Makita K, Katsuyama K, Imai T. Blockade of nuclear factor-kappaB activation prevents hypodynamic shock and gastric hypoperfusion induced by endotoxin in anesthetized dogs. Intensive Care Med. 2005 May;31(5):718-23. doi: 10.1007/s00134-005-2617-1. Epub 2005 Apr 6. PMID: 15812625.
