YS8

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 466143

CAS#: unknown

Description: YS8 is a novel TICT-based fluorescent probe, inhibiting the formation of TICT state and producing a clear light-up fluorescent signal, discriminating HSA from other proteins including the bovine serum albumin (BSA).

Chemical Structure

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YS8
CAS# unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 466143
Name: YS8
CAS#: unknown
Chemical Formula: C36H28N2
Exact Mass: 488.23
Molecular Weight: 488.634
Elemental Analysis: C, 88.49; H, 5.78; N, 5.73

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: YS8; YS 8; YS-8;

IUPAC/Chemical Name: (E)-2-(4-(2-methylstyryl)phenyl)-1,4,5-triphenyl-1H-imidazole

InChi Key: DQGRTPFPVSZEES-DARPEHSRSA-N

InChi Code: InChI=1S/C36H28N2/c1-27-13-11-12-14-29(27)24-21-28-22-25-32(26-23-28)36-37-34(30-15-5-2-6-16-30)35(31-17-7-3-8-18-31)38(36)33-19-9-4-10-20-33/h2-26H,1H3/b24-21+

SMILES Code: CC1=CC=CC=C1/C=C/C2=CC=C(C3=NC(C4=CC=CC=C4)=C(C5=CC=CC=C5)N3C6=CC=CC=C6)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 488.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Luo Y, Yu QQ, Gao JJ, Lang XX, Li HY, Yu XF, Qi XY, Wang MQ. Design, synthesis and mechanistic studies of a TICT based fluorogenic probe for lighting up protein HSA. Bioorg Med Chem Lett. 2021 Dec 1;53:128438. doi: 10.1016/j.bmcl.2021.128438. Epub 2021 Nov 2. PMID: 34740774.

2: Yuan B, Zhu W, Hung I, Gan Z, Aitken B, Sen S. Structure and Chemical Order in S-Se Binary Glasses. J Phys Chem B. 2018 Dec 20;122(50):12219-12226. doi: 10.1021/acs.jpcb.8b10052. Epub 2018 Dec 11. PMID: 30485101.

3: Tang H, Shi X, Wang X, Hao H, Zhang XM, Zhang LP. Environmental Controls Over Actinobacteria Communities in Ecological Sensitive Yanshan Mountains Zone. Front Microbiol. 2016 Mar 22;7:343. doi: 10.3389/fmicb.2016.00343. PMID: 27047461; PMCID: PMC4801888.

4: Seo MJ, Lee BS, Pyun YR, Park H. Isolation and characterization of N-acylhomoserine lactonase from the thermophilic bacterium, Geobacillus caldoxylosilyticus YS-8. Biosci Biotechnol Biochem. 2011;75(9):1789-95. doi: 10.1271/bbb.110322. Epub 2011 Sep 7. PMID: 21897031.

5: Ignatovich O, Cooper M, Kulesza HM, Beggs JD. Cloning and characterisation of the gene encoding the ribosomal protein S5 (also known as rp14, S2, YS8) of Saccharomyces cerevisiae. Nucleic Acids Res. 1995 Nov 25;23(22):4616-9. doi: 10.1093/nar/23.22.4616. PMID: 8524651; PMCID: PMC307434.

6: Wen BH, Yu SR, Yu GQ, Li QJ, Zhang X. Analysis of proteins and lipopolysaccharides from Chinese isolates of Coxiella burnetii with monoclonal antibodies. Acta Virol. 1991 Nov;35(6):538-44. PMID: 1687637.

7: Day ED, Hashim GA, Potter NT, Lazarus KJ. Immunochemical analysis of Lewis rat antisera to the synthetic encephalitogenic peptide S49. Neurochem Res. 1985 Dec;10(12):1587-603. doi: 10.1007/BF00988601. PMID: 2418380.

8: Otaka E, Higo K, Itoh T. Yeast ribosomal proteins. VIII. Isolation of two proteins and sequence characterization of twenty-four proteins from cytoplasmic ribosomes. Mol Gen Genet. 1984;195(3):544-6. doi: 10.1007/BF00341461. PMID: 18782943.

9: Otaka E, Higo K, Osawa S. Isolation of seventeen proteins and amino-terminal amino acid sequences of eight proteins from cytoplasmic ribosomes of yeast. Biochemistry. 1982 Sep 14;21(19):4545-50. doi: 10.1021/bi00262a005. PMID: 6814480.