7C1 polymer

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 556071

CAS#: Unknown

Description: 7C1 polymer was removed for commercial reasons.


Chemical Structure

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7C1 polymer
CAS# Unknown

Theoretical Analysis

MedKoo Cat#: 556071
Name: 7C1 polymer
CAS#: Unknown
Chemical Formula:
Exact Mass: 0.00
Molecular Weight: 0.000
Elemental Analysis:

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: 7C1 polymer;

IUPAC/Chemical Name: poly(ethyleneamine) with C15 lipid.

InChi Key: N/A

InChi Code: N/A

SMILES Code: NCCN(CCNCC(O)CCCCCCCCCCCCC)CCNCCN(CCNCCN(CCN(CCNCCNCC(O)CCCCCCCCCCCCC)CCNCC(O)CCCCCCCCCCCCC)CCNCC(O)CCCCCCCCCCCCC)CCNCCNCC(O)CCCCCCCCCCCCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Biological target: 7C1 is a low-molecular weight, ionizable polymer that forms nanoparticles.
In vitro activity: TBD
In vivo activity: To test the ability of 7C1 nanoparticles to achieve effective gene silencing in the endothelium, Tie2 was selected as the target gene because of its putative endothelial cell specificity. After confirming sequence homology of the Tie2 siRNA target site in mouse and nonhuman primate, the efficacy of the Tie2 siRNA formulated in 7C1 nanoparticles was first analyzed in a dose-response study in mice. he particle sizes measured by dynamic light scattering of the Tie2 and Luc control 7C1 siRNA nanoparticles were 86.8 ± 2.6 nm and 109.6 ± 2.6 nm, respectively. Reference: Sci Adv. 2018 Jun 27;4(6):eaar8409. https://pubmed.ncbi.nlm.nih.gov/29963629/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
To be determined 0.0 0.00

Preparing Stock Solutions

The following data is based on the product molecular weight 0.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Khan OF, Kowalski PS, Doloff JC, Tsosie JK, Bakthavatchalu V, Winn CB, Haupt J, Jamiel M, Langer R, Anderson DG. Endothelial siRNA delivery in nonhuman primates using ionizable low-molecular weight polymeric nanoparticles. Sci Adv. 2018 Jun 27;4(6):eaar8409. doi: 10.1126/sciadv.aar8409. PMID: 29963629; PMCID: PMC6021147.
In vitro protocol: TBD
In vivo protocol: 1. Khan OF, Kowalski PS, Doloff JC, Tsosie JK, Bakthavatchalu V, Winn CB, Haupt J, Jamiel M, Langer R, Anderson DG. Endothelial siRNA delivery in nonhuman primates using ionizable low-molecular weight polymeric nanoparticles. Sci Adv. 2018 Jun 27;4(6):eaar8409. doi: 10.1126/sciadv.aar8409. PMID: 29963629; PMCID: PMC6021147.

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Dahlman JE, Barnes C, Khan O, Thiriot A, Jhunjunwala S, Shaw TE, Xing Y, Sager HB, Sahay G, Speciner L, Bader A, Bogorad RL, Yin H, Racie T, Dong Y, Jiang S, Seedorf D, Dave A, Sandu KS, Webber MJ, Novobrantseva T, Ruda VM, Lytton-Jean AKR, Levins CG, Kalish B, Mudge DK, Perez M, Abezgauz L, Dutta P, Smith L, Charisse K, Kieran MW, Fitzgerald K, Nahrendorf M, Danino D, Tuder RM, von Andrian UH, Akinc A, Schroeder A, Panigrahy D, Kotelianski V, Langer R, Anderson DG. In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight. Nat Nanotechnol. 2014 Aug;9(8):648-655. doi: 10.1038/nnano.2014.84. Epub 2014 May 11. PMID: 24813696; PMCID: PMC4207430.