MedKoo Biosciences

Bisphosphocin Nu-3
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 577817

CAS#: 403717-06-6

Description: NU-3, also known as Bisphosphocin NU-3, is a protonated modified nucleotide with antimicrobial activity. Nu-3 had a wide antibacterial spectrum to Gram-positive, Gram-negative and some resistant bacteria. The MIC values of Nu-3 against all tested MRSA and MSSA were roughly in a same range while MICs of Oxacillin and Vancomycin varied between the bacteria tested. In the mouse model of skin wound infection study, the treatment with 5% Nu-3 glycerine solution also showed comparable therapeutic effects to Ciprofloxacin Hydrochloride Ointment. Nu-3 represents a new class of antibacterial agents for treating topical infections and acts via a different mechanism from conventional antibiotics.

Chemical Structure

Bisphosphocin Nu-3

CAS# 403717-06-6

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 577817
Name: Bisphosphocin Nu-3
CAS#: 403717-06-6
Chemical Formula: C18H32N2O11P2
Exact Mass: 514.15
Molecular Weight: 514.405
Elemental Analysis: C, 42.03; H, 6.27; N, 5.45; O, 34.21; P, 12.04

Price and Availability

Size	Price	Availability
10mg	USD 550	Ready to ship
25mg	USD 950	Ready to ship
50mg	USD 1650	Ready to ship
1mg	USD 150	Ready to ship
5mg	USD 350	Ready to ship
100mg	USD 2950	Ready to ship
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Bisphosphocin NU-3; NU-3; NU 3; NU3;

IUPAC/Chemical Name: ((2R,3S,5R)-3-((butoxy(hydroxy)phosphoryl)oxy)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl butyl hydrogen phosphate

InChi Key: ZXQBUNYVGNOEBQ-ARFHVFGLSA-N

InChi Code: InChI=1S/C18H32N2O11P2/c1-4-6-8-27-32(23,24)29-12-15-14(31-33(25,26)28-9-7-5-2)10-16(30-15)20-11-13(3)17(21)19-18(20)22/h11,14-16H,4-10,12H2,1-3H3,(H,23,24)(H,25,26)(H,19,21,22)/t14-,15+,16+/m0/s1

SMILES Code: CCCCOP(=O)(O)OC[C@H]1O[C@H](C[C@@H]1OP(=O)(O)OCCCC)N2C=C(C)C(=O)NC2=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Product Data

Instruction:

View handling instruction

Biological target:	NU-3, also known as Bisphosphocin NU-3, is a protonated modified nucleotide with antimicrobial activity.
In vitro activity:	TBD
In vivo activity:	TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 514.404500000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	TBD
In vitro protocol:	TBD
In vivo protocol:	TBD

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1: Babot-Marquillas C, Sánchez-Martín MJ, Amigo JM, Yousef I, H Valido I, Boada R, Valiente M. Tooth whitening effects on dental enamel, oxidation or reduction? Comparison of physicochemical alterations in bovine enamel using Synchrotron- based Micro-FTIR. Dent Mater. 2022 Apr;38(4):670-679. doi: 10.1016/j.dental.2022.02.006. Epub 2022 Mar 5. PMID: 35256209. 2: Sa Y, Jiang T, Li BY, Wang ZJ, Wang ZH, Wang YN. [Effects of three at-home bleaching agents on enamel structure and structure-related mechanical properties]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2012 May;47(5):281-6. Chinese. doi: 10.3760/cma.j.issn.1002-0098.2012.05.007. PMID: 22883823. 3: Zhao W. Measurement of Raman χ(3) and theoretical estimation of DOVE four wave mixing of hydrogen peroxide. J Phys Chem A. 2011 Jun 23;115(24):6525-30. doi: 10.1021/jp202977v. Epub 2011 May 18. PMID: 21591714. 4: Cao S, Sun LQ, Wang M. Antimicrobial activity and mechanism of action of Nu-3, a protonated modified nucleotide. Ann Clin Microbiol Antimicrob. 2011 Jan 14;10:1. doi: 10.1186/1476-0711-10-1. PMID: 21232163; PMCID: PMC3031213. 5: Sun J, Hu Y, Cao S, Zhang G, Sun LQ, Wang M. Acute, multiple-dose dermal and genetic toxicity of Nu-3: a novel antimicrobial agent. J Biomed Biotechnol. 2010;2010:362524. doi: 10.1155/2010/362524. Epub 2010 Jul 20. PMID: 20706607; PMCID: PMC2914288. 6: Xue W, He H, Zhu J, Yuan P. FTIR investigation of CTAB-Al-montmorillonite complexes. Spectrochim Acta A Mol Biomol Spectrosc. 2007 Jul;67(3-4):1030-6. doi: 10.1016/j.saa.2006.09.024. Epub 2006 Sep 27. PMID: 17289428. 7: Feng M, Tachikawa H, Wang X, Pfister TD, Gengenbach AJ, Lu Y. Resonance Raman spectroscopy of cytochrome c peroxidase variants that mimic manganese peroxidase. J Biol Inorg Chem. 2003 Sep;8(7):699-706. doi: 10.1007/s00775-003-0460-9. Epub 2003 Jul 9. PMID: 14505074. 8: Pleshko NL, Boskey AL, Mendelsohn R. An FT-IR microscopic investigation of the effects of tissue preservation on bone. Calcif Tissue Int. 1992 Jul;51(1):72-7. doi: 10.1007/BF00296221. PMID: 1393781. 9: Oosterhof GO, Smits GA, de Ruyter AE, Schalken JA, Debruyne FM. Effects of high-energy shock waves combined with biological response modifiers in different human kidney cancer xenografts. Ultrasound Med Biol. 1991;17(4):391-9. doi: 10.1016/0301-5629(91)90139-n. PMID: 1949350. 10: Combes M, Moroz VI, Crovisier J, Encrenaz T, Bibring JP, Grigoriev AV, Sanko NF, Coron N, Crifo JF, Gispert R, Bockelée-Morvan D, Nikolsky YuV, Krasnopolsky VA, Owen T, Emerich C, Lamarre JM, Rocard F. The 2.5-12 micrometers spectrum of comet Halley from the IKS-VEGA experiment. Icarus. 1988;76:404-36. doi: 10.1016/0019-1035(88)90013-9. PMID: 11538667.

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