UR-MB-158

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465935

CAS#: unknown

Description: UR-MB-158 is a novel H2 receptor agonist, functionally stimulating human cardiac H2 receptors in vitro and in vivo.

Chemical Structure

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UR-MB-158
CAS# unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 465935
Name: UR-MB-158
CAS#: unknown
Chemical Formula: C15H21N7OS
Exact Mass: 347.15
Molecular Weight: 347.441
Elemental Analysis: C, 51.85; H, 6.09; N, 28.22; O, 4.60; S, 9.23

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: UR-MB-158; URMB-158; UR MB-158; UR-MB158; UR-MB 158; URMB158; UR MB 158;

IUPAC/Chemical Name: (S,E)-1-(amino((3-(5-amino-1,3,4-thiadiazol-2-yl)propyl)amino)methylene)-3-(1-phenylethyl)urea

InChi Key: CDGJSIMJNZNZFE-JTQLQIEISA-N

InChi Code: InChI=1S/C15H21N7OS/c1-10(11-6-3-2-4-7-11)19-15(23)20-13(16)18-9-5-8-12-21-22-14(17)24-12/h2-4,6-7,10H,5,8-9H2,1H3,(H2,17,22)(H4,16,18,19,20,23)/t10-/m0/s1

SMILES Code: N/C(NCCCC1=NN=C(N)S1)=N\C(N[C@H](C2=CC=CC=C2)C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 347.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Gergs U, Büxel ML, Bresinsky M, Kirchhefer U, Fehse C, Höring C, Hofmann B, Marušáková M, Čináková A, Schwarz R, Pockes S, Neumann J. Cardiac Effects of Novel Histamine H2 Receptor Agonists. J Pharmacol Exp Ther. 2021 Nov;379(3):223-234. doi: 10.1124/jpet.121.000822. Epub 2021 Sep 17. PMID: 34535565.