TAK-653
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MedKoo CAT#: 465874

CAS#: 1358751-06-0

Description: TAK-653 is a novel AMPA receptor potentiator, strictly potentiating a glutamate-induced Ca2+ influx in hGluA1i-expressing CHO cells through structural interference at Ser743 in GluA1,

Chemical Structure

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TAK-653
CAS# 1358751-06-0
Instruction

Theoretical Analysis

MedKoo Cat#: 465874
Name: TAK-653
CAS#: 1358751-06-0
Chemical Formula: C19H23N3O3S
Exact Mass: 373.15
Molecular Weight: 373.471
Elemental Analysis: C, 61.10; H, 6.21; N, 11.25; O, 12.85; S, 8.58

Price and Availability

Size Price Availability Quantity
5mg USD 750 2 Weeks
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Synonym: TAK-653; TAK653; TAK 653; NBI-1065845; NBI1065845; NBI 1065845; osavampator

IUPAC/Chemical Name: 9-(4-(cyclohexyloxy)phenyl)-7-methyl-3,4-dihydropyrazino[2,1-c][1,2,4]thiadiazine 2,2-dioxide

InChi Key: PXJBHEHFVQVDDS-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H23N3O3S/c1-14-13-22-11-12-26(23,24)21-19(22)18(20-14)15-7-9-17(10-8-15)25-16-5-3-2-4-6-16/h7-10,13,16H,2-6,11-12H2,1H3

SMILES Code: CC1=CN(CC2)C(C(C3=CC=C(OC4CCCCC4)C=C3)=N1)=NS2(=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:
Product Data
Instruction:
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Preparing Stock Solutions

The following data is based on the product molecular weight 373.471000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Hara H, Suzuki A, Kunugi A, Tajima Y, Yamada R, Kimura H. TAK-653, an AMPA receptor potentiator with minimal agonistic activity, produces an antidepressant-like effect with a favorable safety profile in rats. Pharmacol Biochem Behav. 2021 Dec;211:173289. doi: 10.1016/j.pbb.2021.173289. Epub 2021 Oct 14. PMID: 34655652. 2: Suzuki A, Kunugi A, Tajima Y, Suzuki N, Suzuki M, Toyofuku M, Kuno H, Sogabe S, Kosugi Y, Awasaki Y, Kaku T, Kimura H. Author Correction: Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement. Sci Rep. 2021 Jul 21;11(1):15255. doi: 10.1038/s41598-021-94772-7. Erratum for: Sci Rep. 2021 Jul 15;11(1):14532. PMID: 34290388; PMCID: PMC8295271. 3: Suzuki A, Kunugi A, Tajima Y, Suzuki N, Suzuki M, Toyofuku M, Kuno H, Sogabe S, Kosugi Y, Awasaki Y, Kaku T, Kimura H. Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement. Sci Rep. 2021 Jul 15;11(1):14532. doi: 10.1038/s41598-021-93888-0. Erratum in: Sci Rep. 2021 Jul 21;11(1):15255. PMID: 34267258; PMCID: PMC8282797. 4: O'Donnell P, Dijkstra FM, Damar U, Quanhong L, de Goede AA, Xu L, Pascual- Leone A, Buhl DL, Zuiker R, Ruijs TQ, Heuberger JAAC, MacMullin P, Lubell M, Asgharnejad M, Murthy V, Rotenberg A, Jacobs GE, Rosen L. Transcranial magnetic stimulation as a translational biomarker for AMPA receptor modulation. Transl Psychiatry. 2021 May 27;11(1):325. doi: 10.1038/s41398-021-01451-2. PMID: 34045439; PMCID: PMC8160137. 5: Witkin JM, Martin AE, Golani LK, Xu NZ, Smith JL. Rapid-acting antidepressants. Adv Pharmacol. 2019;86:47-96. doi: 10.1016/bs.apha.2019.03.002. Epub 2019 Apr 24. PMID: 31378256.