TASIN-1
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465779

CAS#: 792927-06-1 (free)

Description: TASIN-1 is a novel inhibitor of truncated APC proteins with anti-cancer activities.

Chemical Structure

img
TASIN-1
CAS# 792927-06-1 (free)
Instruction

Theoretical Analysis

MedKoo Cat#: 465779
Name: TASIN-1
CAS#: 792927-06-1 (free)
Chemical Formula: C18H28N2O3S
Exact Mass: 352.18
Molecular Weight: 352.493
Elemental Analysis: C, 61.33; H, 8.01; N, 7.95; O, 13.62; S, 9.10

Price and Availability

Size Price Availability Quantity
1mg USD 410 2 Weeks
Bulk inquiry

Related CAS #: 1678515-13-3 (HCl)   792927-06-1 (free)  

Synonym: TASIN-1; TASIN1; TASIN 1; Truncated APC selective inhibitor-1; Truncated APC selective inhibitor 1;

IUPAC/Chemical Name: 1'-((4-methoxyphenyl)sulfonyl)-4-methyl-1,4'-bipiperidine

InChi Key: XCBHYDPDIJQQGM-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)16-9-13-20(14-10-16)24(21,22)18-5-3-17(23-2)4-6-18/h3-6,15-16H,7-14H2,1-2H3

SMILES Code: CC1CCN(C2CCN(S(=O)(C3=CC=C(OC)C=C3)=O)CC2)CC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 352.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Wang W, Zhang L, Morlock L, Williams NS, Shay JW, De Brabander JK. Design and Synthesis of TASIN Analogues Specifically Targeting Colorectal Cancer Cell Lines with Mutant Adenomatous Polyposis Coli (APC). J Med Chem. 2019 May 23;62(10):5217-5241. doi: 10.1021/acs.jmedchem.9b00532. Epub 2019 May 9. PMID: 31070915; PMCID: PMC7252524.

2: Zhang L, Kim SB, Luitel K, Shay JW. Cholesterol Depletion by TASIN-1 Induces Apoptotic Cell Death through the ER Stress/ROS/JNK Signaling in Colon Cancer Cells. Mol Cancer Ther. 2018 May;17(5):943-951. doi: 10.1158/1535-7163.MCT-17-0887. Epub 2018 Feb 21. PMID: 29467273.

3: Zhang L, Theodoropoulos PC, Eskiocak U, Wang W, Moon YA, Posner B, Williams NS, Wright WE, Kim SB, Nijhawan D, De Brabander JK, Shay JW. Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer. Sci Transl Med. 2016 Oct 19;8(361):361ra140. doi: 10.1126/scitranslmed.aaf8127. PMID: 27798265; PMCID: PMC7262871.