XP5

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465752

CAS#: unknown

Description: XP5 is a potent HDAC6 inhibitor with an IC50 of 31 nM and excellent HDAC6 selectivity. XP5 also displayed high antiproliferative activity against various cancer cell lines including the HDACi-resistant YCC3/7 gastric cancer cells (IC50 = 0.16−2.31 μM), better than CAY10603.

Chemical Structure

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XP5
CAS# unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 465752
Name: XP5
CAS#: unknown
Chemical Formula: C19H25N3O5S
Exact Mass: 407.15
Molecular Weight: 407.485
Elemental Analysis: C, 56.00; H, 6.18; N, 10.31; O, 19.63; S, 7.87

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: XP5; XP 5; XP-5;

IUPAC/Chemical Name: 2-(2,4-dimethoxyphenyl)-N-(7-(hydroxyamino)-7-oxoheptyl)thiazole-5-carboxamide

InChi Key: KPMUSOQFDJSLDU-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H25N3O5S/c1-26-13-8-9-14(15(11-13)27-2)19-21-12-16(28-19)18(24)20-10-6-4-3-5-7-17(23)22-25/h8-9,11-12,25H,3-7,10H2,1-2H3,(H,20,24)(H,22,23)

SMILES Code: COC1=CC(OC)=CC=C1C2=NC=C(C(NCCCCCCC(NO)=O)=O)S2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 407.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Peng X, Li L, Chen J, Ren Y, Liu J, Yu Z, Cao H, Chen J. Discovery of Novel Histone Deacetylase 6 (HDAC6) Inhibitors with Enhanced Antitumor Immunity of Anti-PD-L1 Immunotherapy in Melanoma. J Med Chem. 2022 Jan 19. doi: 10.1021/acs.jmedchem.1c01863. Epub ahead of print. PMID: 35043615.