WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 556057

CAS#: 302941-52-2

Description: SWN41522, also known as DUPA and FN11, is a potent Urea-​Based Inhibitor of Glutamate Carboxypeptidase II (NAALADase). In vivo antitumor tests using U-​87 glioblastoma xenograft showed that FN11 reduced tumor vol. to a value of ∼0.4-​0.6 (at 10 or 100 μM) after 4 days treatment, and ∼ 1.0 (at both dosages) after 7 days treatment. The antiangiogenesis activity of FN11 was examd. with similarly grown tumors, and revealed a preponderance of avascular and low vascular areas in tumors treated with FN11 at 100 μM. It was first reported in patent WO 2000064911 and Journal of Medicinal Chemistry (2001), 44(3), 298-301. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

CAS# 302941-52-2

Theoretical Analysis

MedKoo Cat#: 556057
Name: SWN41522
CAS#: 302941-52-2
Chemical Formula: C11H16N2O9
Exact Mass: 320.0856
Molecular Weight: 320.254
Elemental Analysis: C, 41.26; H, 5.04; N, 8.75; O, 44.96

Price and Availability

Size Price Availability Quantity
100.0mg USD 950.0 2 Weeks
200.0mg USD 1650.0 2 Weeks
500.0mg USD 2950.0 2 Weeks
1.0g USD 3950.0 2 Weeks
2.0g USD 6250.0 2 Weeks
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Synonym: DUPA; FN11; FN-11; FN 11; SWN41522; SWN-41522; SWN 41522;

IUPAC/Chemical Name: N,N'-Carbonylbis[L-glutamic acid]


InChi Code: InChI=1S/C11H16N2O9/c14-7(15)3-1-5(9(18)19)12-11(22)13-6(10(20)21)2-4-8(16)17/h5-6H,1-4H2,(H,14,15)(H,16,17)(H,18,19)(H,20,21)(H2,12,13,22)/t5-,6-/m0/s1

SMILES Code: O=C(N[C@@H](CCC(O)=O)C(O)=O)N[C@@H](CCC(O)=O)C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 320.254 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Kozikowski AP, Nan F, Conti P, Zhang J, Ramadan E, Bzdega T, Wroblewska B, Neale JH, Pshenichkin S, Wroblewski JT. Design of remarkably simple, yet potent urea-based inhibitors of glutamate carboxypeptidase II (NAALADase). J Med Chem. 2001 Feb 1;44(3):298-301. doi: 10.1021/jm000406m. PMID: 11462970.


100.0mg / USD 950.0