WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 556050
Description: dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP based on Cereblon ligand. dCBP-1 is exceptionally potent at killing multiple myeloma cells and can abolish the enhancer that drives MYC oncogene expression. As an efficient degrader of this unique class of acetyltransferases, dCBP-1 is a useful tool alongside domain inhibitors for dissecting the mechanism by which these factors coordinate enhancer activity in normal and diseased cells.
MedKoo Cat#: 556050
Chemical Formula: C51H63F2N11O10
Exact Mass: 1027.4727
Molecular Weight: 1028.1288
Elemental Analysis: C, 59.58; H, 6.18; F, 3.70; N, 14.99; O, 15.56
Synonym: dCBP-1; dCBP 1; dCBP1;
IUPAC/Chemical Name: 5H-Pyrazolo[4,3-c]pyridine-5-carboxamide, 3-[7-(difluoromethyl)-3,4-dihydro-6-(1-methyl-1Hpyrazol-4-yl)-1(2H)-quinolinyl]-1-[1-[15-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]-1-oxo-4,7,10,13-tetraoxapentadec-1-yl]-4-piperidinyl]-1,4,6,7-tetrahydro-N-methyl-
SMILES Code: O=C(N1CCC(N(C2CCN(C(CCOCCOCCOCCOCCNC3=CC4=C(C(N(C(CC5)C(NC5=O)=O)C4=O)=O)C=C3)=O)CC2)N=C6N7CCCC8=C7C=C(C(F)F)C(C9=CN(C)N=C9)=C8)=C6C1)NC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 1028.1288 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Lieberman WK, Jing Y, Meier JL. Chemical control of multidomain acetyltransferase activity. Cell Chem Biol. 2021 Apr 15;28(4):433-435. doi: 10.1016/j.chembiol.2021.03.015. PMID: 33861955.
2: Vannam R, Sayilgan J, Ojeda S, Karakyriakou B, Hu E, Kreuzer J, Morris R, Herrera Lopez XI, Rai S, Haas W, Lawrence M, Ott CJ. Targeted degradation of the enhancer lysine acetyltransferases CBP and p300. Cell Chem Biol. 2021 Apr 15;28(4):503-514.e12. doi: 10.1016/j.chembiol.2020.12.004. Epub 2021 Jan 4. PMID: 33400925.