WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 556047
Description: MRN73473, also known as Menin-MLL inhibitor 20, is an irreversible menin-MLL interaction inhibitor with antitumor activities. This compound was first reported in patent WO2020142557A1 (compound 6). This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
MedKoo Cat#: 556047
Chemical Formula: C33H40N8O4
Exact Mass: 612.3173
Molecular Weight: 612.735
Elemental Analysis: C, 64.69; H, 6.58; N, 18.29; O, 10.44
Synonym: Menin-MLL inhibitor 20; MRN73473; MRN-73473; MRN 73473;
IUPAC/Chemical Name: tert-butyl (R)-(1-((2-((4-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl)carbamoyl)pyridin-4-yl)methyl)piperidin-3-yl)carbamate
InChi Key: MPFHTFMFYAODPE-RUZDIDTESA-N
InChi Code: InChI=1S/C33H40N8O4/c1-33(2,3)45-32(43)38-25-5-4-12-40(20-25)19-22-10-11-34-28(17-22)31(42)37-24-8-6-23(7-9-24)27-18-26-29(39-27)35-21-36-30(26)41-13-15-44-16-14-41/h6-11,17-18,21,25H,4-5,12-16,19-20H2,1-3H3,(H,37,42)(H,38,43)(H,35,36,39)/t25-/m1/s1
SMILES Code: O=C(OC(C)(C)C)N[C@H]1CN(CC2=CC(C(NC3=CC=C(C4=CC5=C(N6CCOCC6)N=CN=C5N4)C=C3)=O)=NC=C2)CCC1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 612.735 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|