N-desethyl Amodiaquine HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 556039

CAS#: 79049-30-2 (HCl)

Description: N-desethyl Amodiaquine is a primary metabolite of the antimalarial compound aminodiaquine, produced by the action of cytochrome P450 isoform 2C8. N-desethyl Amodiaquine is highly active against P. falciparum and can synergize with amodiaquine.

Chemical Structure

N-desethyl Amodiaquine HCl
CAS# 79049-30-2 (HCl)

Theoretical Analysis

MedKoo Cat#: 556039
Name: N-desethyl Amodiaquine HCl
CAS#: 79049-30-2 (HCl)
Chemical Formula: C18H20Cl3N3O
Exact Mass:
Molecular Weight: 400.728
Elemental Analysis: C, 53.95; H, 5.03; Cl, 26.54; N, 10.49; O, 3.99

Price and Availability

Size Price Availability Quantity
100.0mg USD 550.0 2 Weeks
200.0mg USD 950.0 2 Weeks
500.0mg USD 1650.0 2 Weeks
1.0g USD 2850.0 2 Weeks
2.0g USD 4950.0 2 Weeks
5.0g USD 7950.0 2 Weeks
Bulk inquiry

Related CAS #: 79049-30-2 (HCl)   79352-78-6 (free base)    

Synonym: N-desethyl Amodiaquine HCl;

IUPAC/Chemical Name: Phenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[(ethylamino)methyl]-, dihydrochloride (9CI)


InChi Code: InChI=1S/C18H18ClN3O.2ClH/c1-2-20-11-12-9-14(4-6-18(12)23)22-16-7-8-21-17-10-13(19)3-5-15(16)17;;/h3-10,20,23H,2,11H2,1H3,(H,21,22);2*1H


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 400.728 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Chalon S, Chughlay MF, Abla N, Marie Tchouatieu A, Haouala A, Hutter B, Lorch U, Macintyre F. Unanticipated CNS Safety Signal in a Placebo-Controlled, Randomized Trial of Co-Administered Atovaquone-Proguanil and Amodiaquine. Clin Pharmacol Ther. 2021 Aug 28. doi: 10.1002/cpt.2404. Epub ahead of print. PMID: 34453327.

2: Nardella F, Mairet-Khedim M, Roesch C, Maher SP, Ke S, Leang R, Leroy D, Witkowski B. Cross-resistance of the chloroquine-derivative AQ-13 with amodiaquine in Cambodian Plasmodium falciparum isolates. J Antimicrob Chemother. 2021 Sep 15;76(10):2565-2568. doi: 10.1093/jac/dkab219. PMID: 34245274; PMCID: PMC8446910.

3: Pernaute-Lau L, Morris U, Msellem M, Mårtensson A, Björkman A, Gil JP. Influence of cytochrome P450 (CYP) 2C8 polymorphisms on the efficacy and tolerability of artesunate-amodiaquine treatment of uncomplicated Plasmodium falciparum malaria in Zanzibar. Malar J. 2021 Feb 15;20(1):90. doi: 10.1186/s12936-021-03620-6. PMID: 33588856; PMCID: PMC7885591.

4: Sottas O, Guidi M, Thieffry B, Schneider M, Décosterd L, Mueller I, Genton B, Csajka C, Senn N. Adherence to intermittent preventive treatment for malaria in Papua New Guinean infants: A pharmacological study alongside the randomized controlled trial. PLoS One. 2019 Feb 6;14(2):e0210789. doi: 10.1371/journal.pone.0210789. PMID: 30726224; PMCID: PMC6364960.

5: Gallay J, Prod'hom S, Mercier T, Bardinet C, Spaggiari D, Pothin E, Buclin T, Genton B, Decosterd LA. LC-MS/MS method for the simultaneous analysis of seven antimalarials and two active metabolites in dried blood spots for applications in field trials: Analytical and clinical validation. J Pharm Biomed Anal. 2018 May 30;154:263-277. doi: 10.1016/j.jpba.2018.01.017. Epub 2018 Feb 3. Erratum in: J Pharm Biomed Anal. 2020 Apr 15;182:112759. PMID: 29579633.

6: Warhurst DC, Craig JC, Raheem KS. Influence of LAR and VAR on Para- Aminopyridine Antimalarials Targetting Haematin in Chloroquine-Resistance. PLoS One. 2016 Aug 2;11(8):e0160091. doi: 10.1371/journal.pone.0160091. Erratum in: PLoS One. 2016;11(8):e0162142. PMID: 27483471; PMCID: PMC4970729.

7: Liu LY, Han YL, Zhu JH, Yu Q, Yang QJ, Lu J, Guo C. A sensitive and high- throughput LC-MS/MS method for inhibition assay of seven major cytochrome P450s in human liver microsomes using an in vitro cocktail of probe substrates. Biomed Chromatogr. 2015 Mar;29(3):437-44. doi: 10.1002/bmc.3294. Epub 2014 Aug 6. PMID: 25098274.

8: Pabón A, Deharo E, Blair S. Plasmodium falciparum: Solanum nudum SN-1 steroid antiplasmodial activity when combined with antimalarial drugs. Exp Parasitol. 2011 Jan;127(1):222-7. doi: 10.1016/j.exppara.2010.08.009. Epub 2010 Aug 22. PMID: 20736008.

9: Sasi P, Abdulrahaman A, Mwai L, Muriithi S, Straimer J, Schieck E, Rippert A, Bashraheil M, Salim A, Peshu J, Awuondo K, Lowe B, Pirmohamed M, Winstanley P, Ward S, Nzila A, Borrmann S. In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa. J Infect Dis. 2009 Jun 1;199(11):1575-82. doi: 10.1086/598862. PMID: 19405863.

10: Hodel EM, Zanolari B, Mercier T, Biollaz J, Keiser J, Olliaro P, Genton B, Decosterd LA. A single LC-tandem mass spectrometry method for the simultaneous determination of 14 antimalarial drugs and their metabolites in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Apr 1;877(10):867-86. doi: 10.1016/j.jchromb.2009.02.006. Epub 2009 Feb 11. PMID: 19249251.

11: Sarrassat S, Sakho M, Le Hesran JY. Biological measure of compliance to Artesunate plus Amodiaquine association: interest in a Mono-Desethyl-Amodiaquine blood assay? Acta Trop. 2009 Apr;110(1):1-6. doi: 10.1016/j.actatropica.2008.11.001. Epub 2008 Nov 14. PMID: 19056331.

12: Davis CB, Bambal R, Moorthy GS, Hugger E, Xiang H, Park BK, Shone AE, O'Neill PM, Ward SA. Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4-aminoquinoline anti-malarials. J Pharm Sci. 2009 Jan;98(1):362-77. doi: 10.1002/jps.21469. PMID: 18563832.

13: Brasseur P. Tolérance de l'amodiaquine [Tolerance of amodiaquine]. Med Trop (Mars). 2007 Jun;67(3):288-90. French. PMID: 17784684.

14: Wennerholm A, Nordmark A, Pihlsgård M, Mahindi M, Bertilsson L, Gustafsson LL. Amodiaquine, its desethylated metabolite, or both, inhibit the metabolism of debrisoquine (CYP2D6) and losartan (CYP2C9) in vivo. Eur J Clin Pharmacol. 2006 Jul;62(7):539-46. doi: 10.1007/s00228-006-0121-3. Epub 2006 Jun 17. PMID: 16783563.

15: Dua VK, Gupta NC, Sharma VP, Subbarao SK. Liquid chromatographic determination of amodiaquine in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Apr 25;803(2):371-4. doi: 10.1016/j.jchromb.2004.01.011. PMID: 15063350.

16: Laurent F, Saivin S, Chretien P, Magnaval JF, Peyron F, Sqalli A, Tufenkji AE, Coulais Y, Baba H, Campistron G, et al. Pharmacokinetic and pharmacodynamic study of amodiaquine and its two metabolites after a single oral dose in human volunteers. Arzneimittelforschung. 1993 May;43(5):612-6. PMID: 8329010.

17: Aymard JP, Wioland C, Ferry R, Netter P, Streiff F. The in vitro effect of amodiaquine on bone marrow granulocyte-macrophage progenitor cells from normal subjects. Fundam Clin Pharmacol. 1992;6(1):1-4. doi: 10.1111/j.1472-8206.1992.tb00086.x. PMID: 1555807.

18: Rouveix B, Coulombel L, Aymard JP, Chau F, Abel L. Amodiaquine-induced immune agranulocytosis. Br J Haematol. 1989 Jan;71(1):7-11. doi: 10.1111/j.1365-2141.1989.tb06266.x. PMID: 2917131.

19: Childs GE, Boudreau EF, Milhous WK, Wimonwattratee T, Pooyindee N, Pang L, Davidson DE Jr. A comparison of the in vitro activities of amodiaquine and desethylamodiaquine against isolates of Plasmodium falciparum. Am J Trop Med Hyg. 1989 Jan;40(1):7-11. doi: 10.4269/ajtmh.1989.40.7. PMID: 2644858.

20: Ellis ME, Steed AJ, Addison GM. Neutropenia associated with dual antimalarial chemoprophylaxis--use of bone-marrow culture as an aid in further drug management. J Infect. 1987 Sep;15(2):147-52. doi: 10.1016/s0163-4453(87)93130-6. PMID: 3668269.