WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 207165

CAS#: 76985-08-5 (free base)

Description: SC10914 is a highly potent PARP inhibitor (PARP1 IC50 = 7.87 nM) with potent anti-proliferative activity against human BRCA deficient tumor cells (MDA-MB-436, BRCA1 deficient, IC50 = 4.03 nM, Capan-1 BRCA2 deficient, IC50 = 11.66 nM) and PTEN deficient tumor cells (HGC-27,PTEN deficient, IC50 = 0.35 μM). SC10914 showed potent anti-tumor activity in BRCA1/2 mutant tumor models and better pharmacokinetics profile has the potential to be selected as the clinical candidate for the treatment of treatment of BRCA1/2 deficient cancers.

Chemical Structure

CAS# 76985-08-5 (free base)

Theoretical Analysis

MedKoo Cat#: 207165
Name: SC-10914
CAS#: 76985-08-5 (free base)
Chemical Formula: C15H15NO2
Exact Mass: 241.1103
Molecular Weight: 241.29
Elemental Analysis: C, 74.67; H, 6.27; N, 5.81; O, 13.26

Price and Availability

Size Price Availability Quantity
100.0mg USD 450.0 2 Weeks
200.0mg USD 750.0 2 Weeks
500.0mg USD 1150.0 2 Weeks
1.0g USD 1950.0 2 Weeks
2.0g USD 2850.0 2 Weeks
5.0g USD 4950.0 2 Weeks
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Related CAS #: 76985-08-5 (free base)   63024-23-7 (HCl)   155760-02-4 (S-isomer)   170080-13-4 (R-isomer)   63087-78-5 (S-isomer HCl)   2159063-18-8 (R-isomer HCl)    

Synonym: SC-10914; SC 10914; SC10914;

IUPAC/Chemical Name: 2-Amino-3-(4-biphenylyl)propanoic acid


InChi Code: InChI=1S/C15H15NO2/c16-14(15(17)18)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9,14H,10,16H2,(H,17,18)


Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 241.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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100.0mg / USD 450.0