WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 465613
CAS#: 1333468-05-5 (racemate)
Description: AZ5576 racemate is a racemic mixture of AZ5576 isomers. AZ5576 is a potent, highly selective, and orally bioavailable inhibitor of Cdk9 that inhibits Cdk9 enzyme activity with an IC50 <5nM and decreases phosphorlyation of Ser2-RNAPII in cells with an IC50 of 96nM. In the MLL-fusion containing acute myeloid leukemia (AML) line, MV411, short-term treatment with AZ5576 led to a rapid dose-dependent decrease in pSer2-RNAPII with concomitant loss of Mcl1 mRNA and protein, resulting in the cleavage and activation of caspase 3 and loss of cell viability.
MedKoo Cat#: 465613
Name: AZ5576 racemate
CAS#: 1333468-05-5 (racemate)
Chemical Formula: C21H24FN3O3
Exact Mass: 385.1802
Molecular Weight: 385.4394
Elemental Analysis: C, 65.44; H, 6.28; F, 4.93; N, 10.90; O, 12.45
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 1333468-12-4 (1R3S-isomer) 2751721-40-9 (1S3R-isomer) 1333468-05-5 (racemate)
Synonym: AZ5576 racemate; AZ5576; AZ 5576; AZ-5576;
IUPAC/Chemical Name: Cyclohexanecarboxamide, 3-(acetylamino)-N-[4-(4-fluoro-2-methoxyphenyl)-2-pyridinyl]-, (1R,3S)-rel-
InChi Key: QNWXRLPZIFMTBK-WBVHZDCISA-N
InChi Code: InChI=1S/C21H24FN3O3/c1-13(26)24-17-5-3-4-15(10-17)21(27)25-20-11-14(8-9-23-20)18-7-6-16(22)12-19(18)28-2/h6-9,11-12,15,17H,3-5,10H2,1-2H3,(H,24,26)(H,23,25,27)/t15-,17+/m1/s1
SMILES Code: O=C([C@H]1C[C@@H](NC(C)=O)CCC1)NC2=NC=CC(C3=CC=C(F)C=C3OC)=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 385.4394 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Hashiguchi T, Bruss N, Best S, Lam V, Danilova O, Paiva CJ, Wolf J, Gilbert EW, Okada CY, Kaur P, Drew L, Cidado J, Hurlin P, Danilov AV. Cyclin-Dependent Kinase-9 Is a Therapeutic Target in MYC-Expressing Diffuse Large B-Cell Lymphoma. Mol Cancer Ther. 2019 Sep;18(9):1520-1532. doi: 10.1158/1535-7163.MCT-18-1023. Epub 2019 Jun 26. PMID: 31243099.
