WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465600

CAS#: 939769-93-4

Description: K34c is a potent and selective α5β1 integrin inhibitor (IC50 = 3.1 nM). K34c inhibits cell survival and migration, inhibits p53-dependent senescence induced by Temozolomide or Ellipticine and promotes apoptosis in U87MG cells. K34c also prevents TGFβ-induced infiltration in vivo and reduces cell adhesion on fibronectin.

Chemical Structure

CAS# 939769-93-4

Theoretical Analysis

MedKoo Cat#: 465600
Name: K34c
CAS#: 939769-93-4
Chemical Formula: C26H29N3O4
Exact Mass: 447.22
Molecular Weight: 447.535
Elemental Analysis: C, 69.78; H, 6.53; N, 9.39; O, 14.30

Price and Availability

Size Price Availability Quantity
5mg USD 650 2 Weeks
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Synonym: K34c; K 34c; K-34c;

IUPAC/Chemical Name: (R)-2-(2,6-dimethylbenzamido)-3-(4-(3-(pyridin-2-ylamino)propoxy)phenyl)propanoic acid


InChi Code: InChI=1S/C26H29N3O4/c1-18-7-5-8-19(2)24(18)25(30)29-22(26(31)32)17-20-10-12-21(13-11-20)33-16-6-15-28-23-9-3-4-14-27-23/h3-5,7-14,22H,6,15-17H2,1-2H3,(H,27,28)(H,29,30)(H,31,32)/t22-/m1/s1


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 44.8 100.00
Ethanol 44.8 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 447.535000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Martinkova E, Maglott A, Leger DY, Bonnet D, Stiborova M, Takeda K, Martin S, Dontenwill M. alpha5beta1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells. Int J Cancer. 2010 Sep 1;127(5):1240-8. doi: 10.1002/ijc.25187. PMID: 20099278.