HPK1-IN-7
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MedKoo CAT#: 471060

CAS#: 2320462-65-3

Description: HPK1-IN-7 is a potent, orally active HPK1 inhibitor. HPK1-IN-7 shows selectivity against IRAK4 (59 nM) and GLK (140 nM).


Chemical Structure

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HPK1-IN-7
CAS# 2320462-65-3

Theoretical Analysis

MedKoo Cat#: 471060
Name: HPK1-IN-7
CAS#: 2320462-65-3
Chemical Formula: C24H22N6O4
Exact Mass: 458.17
Molecular Weight: 458.480
Elemental Analysis: C, 62.87; H, 4.84; N, 18.33; O, 13.96

Price and Availability

Size Price Availability Quantity
25mg USD 850 2 Weeks
50mg USD 1450 2 Weeks
100mg USD 2450 2 Weeks
200mg USD 3950 2 Weeks
500mg USD 4950 2 Weeks
1g USD 6950 2 Weeks
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Related CAS #: 2320462-65-3    

Synonym: HPK1-IN-7 ; HPK1-IN 7, HPK1-IN7

IUPAC/Chemical Name: (S)-5-((4-((2-hydroxy-1-phenylethyl)amino)-5-(1,3,4-oxadiazol-2-yl)pyrimidin-2-yl)amino)-3,3-dimethylisobenzofuran-1(3H)-one

InChi Key: RVSSNRBUPQUIEG-LJQANCHMSA-N

InChi Code: InChI=1S/C24H22N6O4/c1-24(2)18-10-15(8-9-16(18)22(32)34-24)27-23-25-11-17(21-30-26-13-33-21)20(29-23)28-19(12-31)14-6-4-3-5-7-14/h3-11,13,19,31H,12H2,1-2H3,(H2,25,27,28,29)/t19-/m1/s1

SMILES Code: OC[C@@H](NC1=NC(NC2=CC(C3(C)C)=C(C(O3)=O)C=C2)=NC=C1C4=NN=CO4)C5=CC=CC=C5

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 458.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Degnan AP, et al. Discovery of Orally Active Isofuranones as Potent, Selective Inhibitors of Hematopoetic Progenitor Kinase 1. ACS Med Chem Lett. 2021;12(3):443-450.