WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 471057
CAS#: 2376255-48-8
Description: Ac-FLTD-CMK is a potent and selective inhibitor of caspases 1, 5 and 4
MedKoo Cat#: 471057
Name: Ac-FLTD-CMK
CAS#: 2376255-48-8
Chemical Formula: C26H37ClN4O8
Exact Mass: 568.23
Molecular Weight: 569.05
Elemental Analysis: C, 54.88; H, 6.55; Cl, 6.23; N, 9.85; O, 22.49
Synonym: Ac-FLTD-CMK
IUPAC/Chemical Name: (4S,7S,10S,13S)-4-benzyl-13-(2-chloroacetyl)-10-((R)-1-hydroxyethyl)-7-isobutyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid
InChi Key: UCWNTWGHVCSMJP-WPUDHWPRSA-N
InChi Code: InChI=1S/C26H37ClN4O8/c1-14(2)10-19(30-24(37)20(28-16(4)33)11-17-8-6-5-7-9-17)25(38)31-23(15(3)32)26(39)29-18(12-22(35)36)21(34)13-27/h5-9,14-15,18-20,23,32H,10-13H2,1-4H3,(H,28,33)(H,29,39)(H,30,37)(H,31,38)(H,35,36)/t15-,18+,19+,20+,23+/m1/s1
SMILES Code: O=C([C@@H](NC(C)=O)CC1=CC=CC=C1)N[C@H](C(N[C@H](C(N[C@H](C(CCl)=O)CC(O)=O)=O)[C@@H](C)O)=O)CC(C)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 569.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Jie Yang, et al. Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6792-6797.
