Ac-FLTD-CMK
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MedKoo CAT#: 471057

CAS#: 2376255-48-8

Description: Ac-FLTD-CMK is a potent and selective inhibitor of caspases 1, 5 and 4


Chemical Structure

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Ac-FLTD-CMK
CAS# 2376255-48-8

Theoretical Analysis

MedKoo Cat#: 471057
Name: Ac-FLTD-CMK
CAS#: 2376255-48-8
Chemical Formula: C26H37ClN4O8
Exact Mass: 568.23
Molecular Weight: 569.05
Elemental Analysis: C, 54.88; H, 6.55; Cl, 6.23; N, 9.85; O, 22.49

Price and Availability

Size Price Availability Quantity
1.0mg USD 750.0 2 Weeks
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Synonym: Ac-FLTD-CMK

IUPAC/Chemical Name: (4S,7S,10S,13S)-4-benzyl-13-(2-chloroacetyl)-10-((R)-1-hydroxyethyl)-7-isobutyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid

InChi Key: UCWNTWGHVCSMJP-WPUDHWPRSA-N

InChi Code: InChI=1S/C26H37ClN4O8/c1-14(2)10-19(30-24(37)20(28-16(4)33)11-17-8-6-5-7-9-17)25(38)31-23(15(3)32)26(39)29-18(12-22(35)36)21(34)13-27/h5-9,14-15,18-20,23,32H,10-13H2,1-4H3,(H,28,33)(H,29,39)(H,30,37)(H,31,38)(H,35,36)/t15-,18+,19+,20+,23+/m1/s1

SMILES Code: O=C([C@@H](NC(C)=O)CC1=CC=CC=C1)N[C@H](C(N[C@H](C(N[C@H](C(CCl)=O)CC(O)=O)=O)[C@@H](C)O)=O)CC(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 569.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Jie Yang, et al. Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6792-6797.