WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 465572
Description: YS-370 is P-gp inhibitor. YS-370 effectively reversed multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 bound directly to P-gp, did not alter expression or subcellular localization of P-gp in SW620/AD300 cells, but increased the intracellular accumulation of paclitaxel. Significantly, oral administration of YS-370 in combination with paclitaxel achieved much stronger antitumor activity in a xenograft model bearing SW620/Ad300 cells than either drug alone.
MedKoo Cat#: 465572
Chemical Formula: C37H35BrN4O3
Exact Mass: 662.1893
Molecular Weight: 663.616
Elemental Analysis: C, 66.97; H, 5.32; Br, 12.04; N, 8.44; O, 7.23
This product is not in stock, which may be available by custom synthesis.
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Synonym: YS-370; YS370; YS 370;
IUPAC/Chemical Name: 4-(3-((4-(1-(2-bromobenzyl)-2-phenyl-1H-indol-3-yl)-7-methoxyquinazolin-6-yl)oxy)propyl)morpholine
InChi Key: WSOJDUFWINGDJI-UHFFFAOYSA-N
InChi Code: InChI=1S/C37H35BrN4O3/c1-43-33-23-31-29(22-34(33)45-19-9-16-41-17-20-44-21-18-41)36(40-25-39-31)35-28-13-6-8-15-32(28)42(24-27-12-5-7-14-30(27)38)37(35)26-10-3-2-4-11-26/h2-8,10-15,22-23,25H,9,16-21,24H2,1H3
SMILES Code: BrC1=C(CN2C(C=CC=C3)=C3C(C4=NC=NC5=CC(OC)=C(OCCCN6CCOCC6)C=C45)=C2C7=CC=CC=C7)C=CC=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 663.616 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Yuan S, Wang B, Dai QQ, Zhang XN, Zhang JY, Zuo JH, Liu H, Chen ZS, Li GB, Wang S, Liu HM, Yu B. Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors. J Med Chem. 2021 Sep 21. doi: 10.1021/acs.jmedchem.1c01452. Epub ahead of print. PMID: 34546748.