WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 465566
CAS#: 1354359-53-7
Description: JW 480 is a potent and selective inhibitor of the serine hydrolase enzyme KIAA1363 (neutral cholesterol ester hydrolase 1 or NCEH1) (IC50 = 20 nM in mouse brain). JW 480 impairs migration, invasion, survival and tumor growth of prostate cancer cell lines in vivo and reduces monoalkylglycerol ether (MAGE) levels.
MedKoo Cat#: 465566
Name: JW 480
CAS#: 1354359-53-7
Chemical Formula: C22H23NO2
Exact Mass: 333.1729
Molecular Weight: 333.431
Elemental Analysis: C, 79.25; H, 6.95; N, 4.20; O, 9.60
Synonym: JW 480; JW480; JW-480;
IUPAC/Chemical Name: 2-isopropylphenyl (2-(naphthalen-2-yl)ethyl)carbamate
InChi Key: PCNJGBMWAZRVEA-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H23NO2/c1-16(2)20-9-5-6-10-21(20)25-22(24)23-14-13-17-11-12-18-7-3-4-8-19(18)15-17/h3-12,15-16H,13-14H2,1-2H3,(H,23,24)
SMILES Code: CC(C1=CC=CC=C1OC(NCCC2=CC=C3C=CC=CC3=C2)=O)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.34 | 100.0 | |
| Ethanol | 33.34 | 100.0 |
The following data is based on the product molecular weight 333.431 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Holly SP, Gera N, Wang P, Wilson A, Guan Z, Lin L, Cooley B, Alfar HR, Patil RG, Piatt R, Leisner TM, Bergmeier W, Majumder R, Parise LV. Ether lipid metabolism by AADACL1 regulates platelet function and thrombosis. Blood Adv. 2019 Nov 26;3(22):3818-3828. doi: 10.1182/bloodadvances.2018030767. PMID: 31770438; PMCID: PMC6880913.
2: Chang JW, Nomura DK, Cravatt BF. A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis. Chem Biol. 2011 Apr 22;18(4):476-84. doi: 10.1016/j.chembiol.2011.02.008. PMID: 21513884; PMCID: PMC3119342.
3: Serwa R, Tate EW. Activity-based profiling for drug discovery. Chem Biol. 2011 Apr 22;18(4):407-9. doi: 10.1016/j.chembiol.2011.04.002. PMID: 21513874.
