JW 480
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MedKoo CAT#: 465566

CAS#: 1354359-53-7

Description: JW 480 is a potent and selective inhibitor of the serine hydrolase enzyme KIAA1363 (neutral cholesterol ester hydrolase 1 or NCEH1) (IC50 = 20 nM in mouse brain). JW 480 impairs migration, invasion, survival and tumor growth of prostate cancer cell lines in vivo and reduces monoalkylglycerol ether (MAGE) levels.

Chemical Structure

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JW 480
CAS# 1354359-53-7
Instruction

Theoretical Analysis

MedKoo Cat#: 465566
Name: JW 480
CAS#: 1354359-53-7
Chemical Formula: C22H23NO2
Exact Mass: 333.17
Molecular Weight: 333.431
Elemental Analysis: C, 79.25; H, 6.95; N, 4.20; O, 9.60

Price and Availability

Size Price Availability Quantity
50mg USD 450 2 Weeks
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 2650 2 Weeks
1g USD 3850 2 Weeks
2g USD 6450 2 Weeks
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Synonym: JW 480; JW480; JW-480;

IUPAC/Chemical Name: 2-isopropylphenyl (2-(naphthalen-2-yl)ethyl)carbamate

InChi Key: PCNJGBMWAZRVEA-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H23NO2/c1-16(2)20-9-5-6-10-21(20)25-22(24)23-14-13-17-11-12-18-7-3-4-8-19(18)15-17/h3-12,15-16H,13-14H2,1-2H3,(H,23,24)

SMILES Code: CC(C1=CC=CC=C1OC(NCCC2=CC=C3C=CC=CC3=C2)=O)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.3 100.00
Ethanol 33.3 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 333.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Holly SP, Gera N, Wang P, Wilson A, Guan Z, Lin L, Cooley B, Alfar HR, Patil RG, Piatt R, Leisner TM, Bergmeier W, Majumder R, Parise LV. Ether lipid metabolism by AADACL1 regulates platelet function and thrombosis. Blood Adv. 2019 Nov 26;3(22):3818-3828. doi: 10.1182/bloodadvances.2018030767. PMID: 31770438; PMCID: PMC6880913.

2: Chang JW, Nomura DK, Cravatt BF. A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis. Chem Biol. 2011 Apr 22;18(4):476-84. doi: 10.1016/j.chembiol.2011.02.008. PMID: 21513884; PMCID: PMC3119342.

3: Serwa R, Tate EW. Activity-based profiling for drug discovery. Chem Biol. 2011 Apr 22;18(4):407-9. doi: 10.1016/j.chembiol.2011.04.002. PMID: 21513874.