UUN-14238
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MedKoo CAT#: 465564

CAS#: 2222114-23-8

Description: UUN-14238 is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand with a terminal piperazine for onward chemistry to generate Protein Degraders with rigid linkers. UUN-14238 is part of a range of functionalized tool molecules for PROTAC® Degrader R&D. This product has no formal name. For the convenience of scientific communication, we named it by combining its InChi Key (3 letters from the first letter of each section) with the last 5 digit of its CAS#) according to MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming).

Chemical Structure

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UUN-14238
CAS# 2222114-23-8
Instruction

Theoretical Analysis

MedKoo Cat#: 465564
Name: UUN-14238
CAS#: 2222114-23-8
Chemical Formula: C17H18ClFN4O4
Exact Mass: 396.10
Molecular Weight: 396.803
Elemental Analysis: C, 51.46; H, 4.57; Cl, 8.93; F, 4.79; N, 14.12; O, 16.13

Price and Availability

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25mg USD 380 2 Weeks
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Synonym: UUN-14238; UUN14238; UUN 14238; Pomalidomide 5'-fluoro-6'-piperazine;

IUPAC/Chemical Name: 2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(piperazin-1-yl)isoindoline-1,3-dione hydrochloride

InChi Key: UQDWELYJNPCIGK-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H17FN4O4.ClH/c18-11-7-9-10(8-13(11)21-5-3-19-4-6-21)17(26)22(16(9)25)12-1-2-14(23)20-15(12)24;/h7-8,12,19H,1-6H2,(H,20,23,24);1H

SMILES Code: FC1=C(C=C2C(N(C3CCC(NC3=O)=O)C(C2=C1)=O)=O)N4CCNCC4.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 396.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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